J. Andreev, J. P. Simon, D. D. Sabatini, J. Kam, G. Plowman et al., Identification of a New Pyk2 Target Protein with Arf-GAP Activity, Molecular and Cellular Biology, vol.19, issue.3, pp.2338-2350, 1999.
DOI : 10.1128/MCB.19.3.2338

N. J. Avdi, J. A. Nick, B. B. Whitlock, M. A. Billstrom, P. M. Henson et al., Tumor Necrosis Factor-?? Activation of the c-Jun N-terminal Kinase Pathway in Human Neutrophils: INTEGRIN INVOLVEMENT IN A PATHWAY LEADING FROM CYTOPLASMIC TYROSINE KINASES TO APOPTOSIS, Journal of Biological Chemistry, vol.276, issue.3, pp.2189-2199, 2001.
DOI : 10.1074/jbc.M007527200

S. Avraham, R. London, Y. Fu, S. Ota, D. Hiregowdara et al., Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain, J. Biol. Chem, vol.270, pp.27742-27751, 1995.

H. Avraham, S. Y. Park, K. Schinkmann, and S. Avraham, RAFTK/Pyk2-mediated cellular signalling, Cellular Signalling, vol.12, issue.3, pp.123-133, 2000.
DOI : 10.1016/S0898-6568(99)00076-5

Y. Banno, K. Ohguchi, N. Matsumoto, M. Koda, M. Ueda et al., Implication of Phospholipase D2 in Oxidant-induced Phosphoinositide 3-Kinase Signaling via Pyk2 Activation in PC12 Cells, Journal of Biological Chemistry, vol.280, issue.16, pp.16319-16324, 2005.
DOI : 10.1074/jbc.M410903200

N. Benbernou, K. Muegge, and S. K. Durum, Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7R??, Journal of Biological Chemistry, vol.275, issue.10, pp.7060-7065, 2000.
DOI : 10.1074/jbc.275.10.7060

A. Blaukat, I. Ivankovic-dikic, E. Gronroos, F. Dolfi, G. Tokiwa et al., Adaptor Proteins Grb2 and Crk Couple Pyk2 with Activation of Specific Mitogen-activated Protein Kinase Cascades, Journal of Biological Chemistry, vol.274, issue.21, pp.14893-14901, 1999.
DOI : 10.1074/jbc.274.21.14893

A. L. Boutillier, P. Kienlen-campard, J. P. Loeffler, F. Depolarization, and . Strappazzon, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway, European Journal of Neuroscience, vol.11, issue.2, pp.355-365, 1999.
DOI : 10.1046/j.1460-9568.1999.00451.x

E. Carboni and W. J. Wojcik, Dihydropyridine Binding Sites Regulate Calcium Influx Through Specific Voltage-Sensitive Calcium Channels in Cerebellar Granule Cells, Journal of Neurochemistry, vol.108, issue.4, pp.1279-1286, 1988.
DOI : 10.1016/0024-3205(84)90100-0

D. Chauhan, T. Hideshima, P. Pandey, S. Treon, G. Teoh et al., RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells, Oncogene, vol.18, issue.48, pp.6733-6740, 1999.
DOI : 10.1038/sj.onc.1203082

J. C. Corvol, E. Valjent, M. Toutant, H. Enslen, T. Irinopoulou et al., Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices, Journal of Biological Chemistry, vol.280, issue.1, pp.660-668, 2005.
DOI : 10.1074/jbc.M411312200

M. J. Courtney, J. J. Lambert, and D. G. Nicholls, The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells, J. Neurosci, vol.10, pp.3873-3879, 1990.

D. Rocca, G. J. Van-biesen, T. Daaka, Y. Luttrell, D. K. Luttrell et al., Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors: CONVERGENCE OF Gi- AND Gq-MEDIATED PATHWAYS ON CALCIUM/CALMODULIN, Pyk2, AND Src KINASE, Journal of Biological Chemistry, vol.272, issue.31, pp.19125-19132, 1997.
DOI : 10.1074/jbc.272.31.19125

P. Derkinderen, M. Toutant, F. Burgaya, L. Bert, M. Siciliano et al., Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide, Science, vol.273, issue.5282, pp.1719-1722, 1996.
DOI : 10.1126/science.273.5282.1719

P. Derkinderen, J. Siciliano, M. Toutant, and J. A. Girault, Differential regulation of FAK+ and PYK2/Cak??, two related tyrosine kinases, in rat hippocampal slices: effects of LPA, carbachol, depolarization and hyperosmolarity, European Journal of Neuroscience, vol.386, issue.5, pp.1667-1675, 1998.
DOI : 10.1046/j.1460-9568.1998.00174.x

S. Desagher, D. Severac, A. Lipkin, C. Bernis, W. Ritchie et al., Genes Regulated in Neurons Undergoing Transcription-dependent Apoptosis Belong to Signaling Pathways Rather than the Apoptotic Machinery, Journal of Biological Chemistry, vol.280, issue.7, pp.5693-5702, 2005.
DOI : 10.1074/jbc.M408971200

URL : https://hal.archives-ouvertes.fr/inserm-00102692

I. Dikic, G. Tokiwa, S. Lev, S. A. Courtneidge, and J. Schlessinger, A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation, Nature, vol.383, issue.6600, pp.547-550, 1996.
DOI : 10.1038/383547a0

D. Mello, S. R. Galli, C. Ciotti, T. Calissano, and P. , Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP., Proceedings of the National Academy of Sciences, vol.90, issue.23, pp.10989-10993, 1993.
DOI : 10.1073/pnas.90.23.10989

P. A. Doroshenko, P. G. Kostyuk, and E. A. Luk-'yanetz, Modulation of calcium current by calmodulin antagonists, Neuroscience, vol.27, issue.3, pp.1073-1080, 1988.
DOI : 10.1016/0306-4522(88)90211-4

C. J. Dougherty, L. A. Kubasiak, D. P. Frazier, H. Li, W. C. Xiong et al., Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation, The FASEB Journal, vol.18, issue.10, pp.1060-1070, 2004.
DOI : 10.1096/fj.04-1505com

T. F. Franke, C. P. Hornik, L. Segev, G. A. Shostak, and C. Sugimoto, PI3K/Akt and apoptosis: size matters, Oncogene, vol.22, issue.56, pp.8983-8998, 2003.
DOI : 10.1038/sj.onc.1207115

J. L. Franklin, J. Jr, and E. M. , Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium, Trends in Neurosciences, vol.15, issue.12, pp.501-508, 1992.
DOI : 10.1016/0166-2236(92)90103-F

J. L. Franklin, C. Sanz-rodriguez, A. Juhasz, T. L. Deckwerth, J. Jr et al., Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation, J. Neurosci, vol.15, pp.643-664, 1995.

V. Gallo, A. Kingsbury, R. Balazs, and O. S. Jorgensen, The role of depolarization in the survival and differentiation of cerebellar granule cells in culture, J. Neurosci, vol.7, pp.2203-2213, 1987.

R. Ginnan and H. A. Singer, CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscle, American Journal of Physiology - Cell Physiology, vol.282, issue.4, pp.754-761, 2002.
DOI : 10.1152/ajpcell.00335.2001

J. A. Girault, A. Costa, P. Derkinderen, J. M. Studler, and M. Toutant, FAK and PYK2/CAKbeta in the nervous system: a link between neuronal activity, plasticity and survival? Trends Neurosci, pp.257-263, 1999.

D. A. Greenberg, C. L. Carpenter, and R. O. Messing, Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels, Brain Research, vol.404, issue.1-2, pp.401-404, 1987.
DOI : 10.1016/0006-8993(87)91403-X

J. Guo, F. Meng, X. Fu, B. Song, X. Yan et al., N-Methyl-d-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats, Neuroscience Letters, vol.355, issue.3, pp.177-180, 2004.
DOI : 10.1016/j.neulet.2003.10.076

N. Hack, H. Hidaka, M. J. Wakefield, and R. Balazs, Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity, Neuroscience, vol.57, issue.1, pp.9-20, 1993.
DOI : 10.1016/0306-4522(93)90108-R

V. Heidinger, P. Manzerra, X. Q. Wang, U. Strasser, S. P. Yu et al., Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/ Src-family kinase pathway in cortical neurons, J. Neurosci, vol.22, pp.5452-5461, 2002.

H. Herzog, J. Nicholl, Y. J. Hort, G. R. Sutherland, and J. Shine, Molecular Cloning and Assignment of FAK2, a Novel Human Focal Adhesion Kinase, to 8p11.2???p22 by Nonisotopicin SituHybridization, Genomics, vol.32, issue.3, pp.484-486, 1996.
DOI : 10.1006/geno.1996.0149

H. Hidaka and T. Tanaka, [17] Naphthalenesulfonamides as calmodulin antagonists, Methods Enzymol, vol.102, pp.185-194, 1983.
DOI : 10.1016/S0076-6879(83)02019-4

Y. Huang, W. Lu, D. W. Ali, K. A. Pelkey, G. M. Pitcher et al., CAK??/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 Hippocampus, Neuron, vol.29, issue.2, pp.485-496, 2001.
DOI : 10.1016/S0896-6273(01)00220-3

I. Ivankovic-dikic, E. Gronroos, A. Blaukat, B. U. Barth, and I. Dikic, Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins, Nature Cell Biology, vol.2, issue.9, pp.574-581, 2000.
DOI : 10.1038/35023515

T. Koike, D. P. Martin, J. Jr, and E. M. , Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells., Proceedings of the National Academy of Sciences, vol.86, issue.16, pp.6421-6425, 1989.
DOI : 10.1073/pnas.86.16.6421

K. Koziak, E. Kaczmarek, S. Y. Park, Y. Fu, S. Avraham et al., RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase, British Journal of Haematology, vol.88, issue.1, pp.134-140, 2001.
DOI : 10.1038/sj.onc.1203422

M. Lafon-cazal, V. Perez, J. Bockaert, and P. Marin, Akt mediates the anti-apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule cells, European Journal of Neuroscience, vol.273, issue.4, pp.575-583, 2002.
DOI : 10.1046/j.1460-9568.2002.02124.x

S. Lev, H. Moreno, R. Martinez, P. Canoll, E. Peles et al., Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions, Nature, vol.376, issue.6543, pp.737-745, 1995.
DOI : 10.1038/376737a0

X. Li, R. C. Dy, W. G. Cance, L. M. Graves, and H. S. Earp, Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase, Journal of Biological Chemistry, vol.274, issue.13, pp.8917-8924, 1999.
DOI : 10.1074/jbc.274.13.8917

J. Melendez, C. Turner, H. Avraham, S. F. Steinberg, E. Schaefer et al., Cardiomyocyte Apoptosis Triggered by RAFTK/pyk2 via Src Kinase Is Antagonized by Paxillin, Journal of Biological Chemistry, vol.279, issue.51, pp.53516-53523, 2004.
DOI : 10.1074/jbc.M408475200

A. N. Meyer, R. F. Gastwirt, D. D. Schlaepfer, and D. J. Donoghue, The Cytoplasmic Tyrosine Kinase Pyk2 as a Novel Effector of Fibroblast Growth Factor Receptor 3 Activation, Journal of Biological Chemistry, vol.279, issue.27, pp.28450-28457, 2004.
DOI : 10.1074/jbc.M403335200

T. M. Miller, J. Jr, and E. M. , Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells, J. Neurosci, vol.16, pp.7487-7495, 1996.

T. M. Miller, M. G. Tansey, J. Jr, E. M. Creedon, and D. J. , Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization-and insulin-like growth factor I-mediated survival of cerebellar granule cells, J. Biol. Chem, vol.272, pp.9847-9853, 1997.

M. Missotten, A. Nichols, K. Rieger, and R. Sadoul, Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein, Cell Death and Differentiation, vol.6, issue.2, pp.124-129, 1999.
DOI : 10.1038/sj.cdd.4400456

F. Strappazzon, Survival response-linked Pyk2 activation during potassium depletion-induced apoptosis of cerebellar granule neurons, Molecular and Cellular Neuroscience, vol.34, issue.3, pp.355-365, 2007.
DOI : 10.1016/j.mcn.2006.11.012

URL : https://hal.archives-ouvertes.fr/inserm-00381805

Y. Nakagawa-yagi, D. K. Choi, N. Ogane, S. Shimada, M. Seya et al., Discovery of a novel compound: insight into mechanisms for acrylamide-induced axonopathy and colchicine-induced apoptotic neuronal cell death, Brain Research, vol.909, issue.1-2, pp.8-19, 2001.
DOI : 10.1016/S0006-8993(01)02608-7

Y. Ogata, M. Takahashi, S. Ueno, K. Takeuchi, T. Okada et al., Antiapoptotic Effect of Endothelin-1 in Rat Cardiomyocytes In Vitro, Hypertension, vol.41, issue.5, pp.1156-1163, 2003.
DOI : 10.1161/01.HYP.0000064342.30653.24

P. Pandey, S. Avraham, S. Kumar, A. Nakazawa, A. Place et al., Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism, Journal of Biological Chemistry, vol.274, issue.15, pp.10140-10144, 1999.
DOI : 10.1074/jbc.274.15.10140

P. Pandey, S. Avraham, A. Place, V. Kumar, P. K. Majumder et al., Bcl-xL Blocks Activation of Related Adhesion Focal Tyrosine Kinase/Proline-rich Tyrosine Kinase 2 and Stress-activated Protein Kinase/c-Jun N-terminal Protein Kinase in the Cellular Response to Methylmethane Sulfonate, Journal of Biological Chemistry, vol.274, issue.13, pp.8618-8623, 1999.
DOI : 10.1074/jbc.274.13.8618

J. H. Park, J. K. Park, K. W. Bae, and H. T. Park, Protein kinase A activity is required for depolarization-induced proline-rich tyrosine kinase 2 and mitogen-activated protein kinase activation in PC12 cells, Neuroscience Letters, vol.290, issue.1, pp.25-28, 2000.
DOI : 10.1016/S0304-3940(00)01313-6

S. Y. Park, H. Avraham, and S. Avraham, Characterization of the Tyrosine Kinases RAFTK/Pyk2 and FAK in Nerve Growth Factor-induced Neuronal Differentiation, Journal of Biological Chemistry, vol.275, issue.26, 2000.
DOI : 10.1074/jbc.M909932199

S. Y. Park, H. K. Avraham, and S. Avraham, RAFTK/Pyk2 Activation Is Mediated by Trans-acting Autophosphorylation in a Src-independent Manner, Journal of Biological Chemistry, vol.279, issue.32, pp.33315-33322, 2004.
DOI : 10.1074/jbc.M313527200

P. Rocic, G. Govindarajan, A. Sabri, . Lucchesi, P. Rocic et al., A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle, Am. J. Physiol. Cell Physiol, vol.268, pp.90-99, 2001.

L. M. Rumsey, R. M. Teague, S. H. Benedict, and M. A. Chan, MIP-1?? Induces Activation of Phosphatidylinositol-3 Kinase That Associates with Pyk-2 and Is Necessary for B-Cell Migration, Experimental Cell Research, vol.268, issue.1, pp.77-83, 2001.
DOI : 10.1006/excr.2001.5272

H. Sasaki, K. Nagura, M. Ishino, H. Tobioka, K. Kotani et al., Cloning and Characterization of Cell Adhesion Kinase ??, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily, Journal of Biological Chemistry, vol.270, issue.36, pp.21206-21219, 1995.
DOI : 10.1074/jbc.270.36.21206

M. R. Sayed, M. P. Sheid, C. M. Stevens, and V. Duronio, Thrombin-stimulated phosphatidylinositol 3-kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation independent, Journal of Cellular Physiology, vol.205, issue.3, pp.314-320, 2000.
DOI : 10.1002/(SICI)1097-4652(200006)183:3<314::AID-JCP3>3.0.CO;2-J

M. H. Schmidt, I. Dikic, and O. Bogler, Src Phosphorylation of Alix/AIP1 Modulates Its Interaction with Binding Partners and Antagonizes Its Activities, Journal of Biological Chemistry, vol.280, issue.5, pp.3414-3425, 2005.
DOI : 10.1074/jbc.M409839200

V. See, A. L. Boutillier, H. Bito, and J. P. Loeffler, Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons, The FASEB Journal, vol.15, issue.1, pp.134-144, 2001.
DOI : 10.1096/fj.00-0106com

C. S. Shi and J. H. Kehrl, PYK2 Links Gqalpha and G13alpha Signaling to NF-kappa B Activation, Journal of Biological Chemistry, vol.276, issue.34, pp.31845-31850, 2001.
DOI : 10.1074/jbc.M101043200

K. Shimoke, S. Yamagishi, M. Yamada, T. Ikeuchi, and H. Hatanaka, Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons, Developmental Brain Research, vol.112, issue.2, pp.245-253, 1999.
DOI : 10.1016/S0165-3806(98)00172-2

J. C. Siciliano, M. Toutant, P. Derkinderen, T. Sasaki, and J. A. Girault, Differential regulation of proline-rich tyrosine kinase 2/cell adhesion kinase beta (PYK2/CAKbeta) and pp125(FAK) by glutamate and depolarization in rat hippocampus, J. Biol. Chem, vol.271, pp.28942-28946, 1996.

R. M. Soler, J. Egea, G. M. Mintenig, C. Sanz-rodriguez, M. Iglesias et al., Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidy linositol-3 kinase-and MAPK-independent pathways, J. Neurosci, vol.18, pp.1230-1239, 1998.

Y. Taniyama, D. S. Weber, P. Rocic, L. Hilenski, M. L. Akers et al., Pyk2- and Src-Dependent Tyrosine Phosphorylation of PDK1 Regulates Focal Adhesions, Molecular and Cellular Biology, vol.23, issue.22, pp.8019-8029, 2003.
DOI : 10.1128/MCB.23.22.8019-8029.2003

D. Tian, V. Litvak, and S. Lev, Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells, J. Neurosci, vol.20, pp.6478-6487, 2000.

G. Tokiwa, I. Dikic, S. Lev, and J. Schlessinger, Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway, Science, vol.273, issue.5276, pp.792-794, 1996.
DOI : 10.1126/science.273.5276.792

Y. Trioulier, S. Torch, B. Blot, N. Cristina, C. Chatellard-causse et al., Alix, a Protein Regulating Endosomal Trafficking, Is Involved in Neuronal Death, Journal of Biological Chemistry, vol.279, issue.3, pp.2046-2052, 2004.
DOI : 10.1074/jbc.M309243200

URL : https://hal.archives-ouvertes.fr/inserm-00381892

H. Ueda, S. Abbi, C. Zheng, and J. L. Guan, Suppression of Pyk2 Kinase and Cellular Activities by Fip200, The Journal of Cell Biology, vol.19, issue.2, pp.423-430, 2000.
DOI : 10.1074/jbc.273.4.2384

P. Vito, L. Pellegrini, C. Guiet, and L. D-'adamio, Cloning of AIP1, a Novel Protein That Associates with the Apoptosis-linked Gene ALG-2 in a Ca2+-dependent Reaction, Journal of Biological Chemistry, vol.274, issue.3, pp.1533-1540, 1999.
DOI : 10.1074/jbc.274.3.1533

L. Wei, Y. Yang, X. Zhang, and Q. Yu, Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis, Oncogene, vol.23, issue.56, pp.9052-9061, 2004.
DOI : 10.1038/sj.onc.1208091

W. C. Xiong and L. Mei, Roles of FAK family kinases in nervous system, Frontiers in Bioscience, vol.8, issue.6, pp.676-682, 2003.
DOI : 10.2741/1116

W. Xiong and J. T. Parsons, Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase, The Journal of Cell Biology, vol.267, issue.2, pp.529-539, 1997.
DOI : 10.1074/jbc.271.47.29993

H. Yu, X. Li, G. S. Marchetto, R. Dy, D. Hunter et al., Activation of a Novel Calcium-dependent Protein-tyrosine Kinase: CORRELATION WITH c-Jun N-TERMINAL KINASE BUT NOT MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION, Journal of Biological Chemistry, vol.271, issue.47, pp.29993-29998, 1996.
DOI : 10.1074/jbc.271.47.29993

E. Zwick, C. Wallasch, H. Daub, and A. Ullrich, Distinct Calcium-dependent Pathways of Epidermal Growth Factor Receptor Transactivation and PYK2 Tyrosine Phosphorylation in PC12 Cells, Journal of Biological Chemistry, vol.274, issue.30, pp.20989-20996, 1999.
DOI : 10.1074/jbc.274.30.20989