C. A. Ahern and R. Horn, Stirring up controversy with a voltage sensor paddle, Trends in Neurosciences, vol.27, issue.6, pp.303-307, 2004.
DOI : 10.1016/j.tins.2004.03.008

C. M. Armstrong, Sodium channels and gating currents, Physiol Rev, vol.61, pp.644-683, 1981.

W. A. Catterall, Molecular properties of voltage-sensitive sodium channels, 1986.

W. A. Catterall, From Ionic Currents to Molecular Mechanisms, Neuron, vol.26, issue.1, pp.13-25, 2000.
DOI : 10.1016/S0896-6273(00)81133-2

S. Cestele and W. A. Catterall, Molecular mechanisms of neurotoxin action on voltage-gated sodium channels, Biochimie, vol.82, issue.9-10, pp.883-892, 2000.
DOI : 10.1016/S0300-9084(00)01174-3

A. Cha, P. C. Ruben, A. L. George, . Jr, E. Fujimoto et al., Voltage Sensors in Domains III and IV, but Not I and II, Are Immobilized by Na+ Channel Fast Inactivation, Neuron, vol.22, issue.1, pp.73-87, 1999.
DOI : 10.1016/S0896-6273(00)80680-7

B. Chanda, O. K. Asamoah, and F. Bezanilla, Coupling Interactions between Voltage Sensors of the Sodium Channel as Revealed by Site-specific Measurements, The Journal of General Physiology, vol.71, issue.3, 2004.
DOI : 10.1085/jgp.103.2.321

B. Chanda and F. Bezanilla, Tracking Voltage-dependent Conformational Changes in Skeletal Muscle Sodium Channel during Activation, The Journal of General Physiology, vol.22, issue.3, pp.629-645, 2002.
DOI : 10.1016/S0006-3495(91)82186-5

L. Q. Chen, V. Santarelli, R. Horn, and R. G. Kallen, A unique role for the S4 segment of domain 4 in the inactivation of sodium channels, The Journal of General Physiology, vol.108, issue.6, pp.549-556, 1996.
DOI : 10.1085/jgp.108.6.549

H. R. Guy and P. Seetharamulu, Molecular model of the action potential sodium channel., Proceedings of the National Academy of Sciences, vol.83, issue.2, pp.508-512, 1986.
DOI : 10.1073/pnas.83.2.508

S. H. Heinemann, H. Terlau, W. Stuhmer, K. Imoto, and S. Numa, Calcium channel characteristics conferred on the sodium channel by single mutations, Nature, vol.356, issue.6368, pp.441-443, 1992.
DOI : 10.1038/356441a0

A. L. Hodgkin and A. F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve, The Journal of Physiology, vol.117, issue.4, pp.500-544, 1952.
DOI : 10.1113/jphysiol.1952.sp004764

K. Izhar, C. Lior, G. Nicolas, G. Dalia, and G. Michael, Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels, The FASEB Journal, vol.18, issue.6, pp.683-689, 2004.
DOI : 10.1096/fj.03-0733com

Y. Jiang, A. Lee, J. Chen, V. Ruta, M. Cadene et al., X-ray structure of a voltage-dependent K+ channel, Nature, vol.22, issue.6935, pp.33-41, 2003.
DOI : 10.1085/JGP.114.4.551

Y. Jiang, V. Ruta, J. Chen, A. Lee, and R. Mackinnon, The principle of gating charge movement in a voltage-dependent K+ channel, Nature, vol.19, issue.6935, pp.42-48, 2003.
DOI : 10.1007/s004240050253

M. Jordan, A. Schallhorn, and F. M. Wurm, Transfecting Mammalian Cells: Optimization of Critical Parameters Affecting Calcium-Phosphate Precipitate Formation, Nucleic Acids Research, vol.24, issue.4, pp.596-601, 1996.
DOI : 10.1093/nar/24.4.596

K. J. Kontis and A. L. Goldin, Sodium Channel Inactivation Is Altered by Substitution of Voltage Sensor Positive Charges, The Journal of General Physiology, vol.98, issue.4, pp.403-413, 1997.
DOI : 10.1126/science.2122520

K. J. Kontis, A. Rounaghi, and A. L. Goldin, Sodium Channel Activation Gating Is Affected by Substitutions of Voltage Sensor Positive Charges in All Four Domains, The Journal of General Physiology, vol.268, issue.4, 1997.
DOI : 10.1016/0896-6273(95)90078-0

Y. Li-smerin, D. H. Hackos, and K. J. Swartz, Channel, The Journal of General Physiology, vol.8, issue.1, pp.33-50, 2000.
DOI : 10.1126/science.2122520

P. Marcotte, L. Q. Chen, R. G. Kallen, and M. Chahine, Effects of Tityus serrulatus Scorpion Toxin ?? on Voltage-Gated Na+ Channels, Circulation Research, vol.80, issue.3, pp.363-369, 1997.
DOI : 10.1161/01.RES.80.3.363

P. Marcotte, L. Q. Chen, R. G. Kallen, and M. Chahine, Effects of Tityus serrulatus Scorpion Toxin ?? on Voltage-Gated Na+ Channels, Circulation Research, vol.80, issue.3, pp.363-369, 1997.
DOI : 10.1161/01.RES.80.3.363

M. F. Martin, L. G. Perez, M. Ayeb, C. Kopeyan, G. Bechis et al., Purification and chemical and biological characterizations of seven toxins from the Mexican scorpion, Centruroides suffusus suffusus, J.Biol.Chem, vol.262, pp.4452-4459, 1987.

N. Mitrovic, A. L. George, . Jr, and R. Horn, Independent Versus Coupled Inactivation in Sodium Channels, The Journal of General Physiology, vol.73, issue.3, pp.451-462, 1998.
DOI : 10.1085/jgp.103.2.321

M. Noda, H. Suzuki, S. Numa, and W. Stuhmer, A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II, FEBS Letters, vol.233, issue.1, pp.213-216, 1989.
DOI : 10.1016/0014-5793(89)81531-5

D. M. Papazian, X. M. Shao, S. A. Seoh, A. F. Mock, Y. Huang et al., Electrostatic interactions of S4 voltage sensor in shaker K+ channel, Neuron, vol.14, issue.6, pp.1293-1301, 1995.
DOI : 10.1016/0896-6273(95)90276-7

R. Planells-cases, A. V. Ferrer-montiel, C. D. Patten, and M. Montal, Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating., Proceedings of the National Academy of Sciences, vol.92, issue.20, pp.9422-9426, 1995.
DOI : 10.1073/pnas.92.20.9422

D. S. Ragsdale, J. C. Mcphee, T. Scheuer, and W. A. Catterall, Molecular determinants of state-dependent block of Na+ channels by local anesthetics, Science, vol.265, issue.5179, pp.1724-1728, 1994.
DOI : 10.1126/science.8085162

S. A. Seoh, D. Sigg, D. M. Papazian, and F. Bezanilla, Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel, Neuron, vol.16, issue.6, pp.1159-1167, 1996.
DOI : 10.1016/S0896-6273(00)80142-7

M. F. Sheets and D. A. Hanck, Molecular Action of Lidocaine on the Voltage Sensors of Sodium Channels, The Journal of General Physiology, vol.6, issue.1, pp.163-175, 2003.
DOI : 10.1016/S0006-3495(93)81292-X

W. Stuhmer, F. Conti, H. Suzuki, X. D. Wang, M. Noda et al., Structural parts involved in activation and inactivation of the sodium channel, Nature, vol.339, issue.6226, pp.597-603, 1989.
DOI : 10.1038/339597a0

H. Terlau, S. H. Heinemann, W. Stuhmer, M. Pusch, F. Conti et al., Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II, FEBS Letters, vol.289, issue.1-2, pp.93-96, 1991.
DOI : 10.1016/0014-5793(91)81159-6

S. K. Tiwari-woodruff, M. A. Lin, C. T. Schulteis, and D. M. Papazian, Channel, The Journal of General Physiology, vol.74, issue.2, pp.123-138, 2000.
DOI : 10.1085/jgp.112.4.457

N. Yang, A. L. George, . Jr, and R. Horn, Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels, Neuron, vol.16, issue.1, pp.113-122, 1996.
DOI : 10.1016/S0896-6273(00)80028-8

N. Yang, A. L. George, . Jr, and R. Horn, Probing the outer vestibule of a sodium channel voltage sensor, Biophysical Journal, vol.73, issue.5, pp.2260-2268, 1997.
DOI : 10.1016/S0006-3495(97)78258-4

N. Yang and R. Horn, Evidence for voltage-dependent S4 movement in sodium channels, Neuron, vol.15, issue.1, pp.213-218, 1995.
DOI : 10.1016/0896-6273(95)90078-0