D. Archer, Collimator for producing an array of microbeams US Patent, 1998.

Y. Assaf, E. Beit-yannai, E. Shohami, E. Berman, and Y. Cohen, Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology, Magnetic Resonance Imaging, vol.15, issue.1, pp.77-85, 1997.
DOI : 10.1016/S0730-725X(96)00246-9

P. A. Barber, L. Hoyte, D. Kirk, T. Foniok, A. Buchan et al., Early T1-and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T Neurosci, Lett, vol.388, pp.54-63, 2005.

E. L. Barbier, L. Liu, E. Grillon, J. F. Payen, J. F. Lebas et al., Focal brain ischemia in rat: acute changes in brain tissueT1 reflect acute increase in brain tissue water content, NMR in Biomedicine, vol.52, issue.8, pp.499-506, 2005.
DOI : 10.1002/nbm.979

P. Barzo, A. Marmarou, P. Fatouros, K. Hayasaki, and C. F. , Contribution of vasogenic and cellular edema to traumatic brain swelling measured by diffusion-weighted imaging, Journal of Neurosurgery, vol.87, issue.6, pp.900-907, 1997.
DOI : 10.3171/jns.1997.87.6.0900

H. Blattmann, Applications of synchrotron X-rays to radiotherapy, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.548, issue.1-2, pp.17-22, 2005.
DOI : 10.1016/j.nima.2005.03.060

S. Boretius, O. Natt, T. Watanabe, R. Tammer, L. Ehrenreich et al., diffusion tensor mapping of the brain of squirrel monkey, rat, and mouse using single-shot STEAM MRI Magma, pp.339-386, 2004.

E. Brauer-krisch, H. Requardt, P. Regnard, S. Corde, E. Siegbahn et al., New irradiation geometry for microbeam radiation therapy, Physics in Medicine and Biology, vol.50, issue.13, pp.3103-3114, 2005.
DOI : 10.1088/0031-9155/50/13/009

F. Calamante, M. F. Lythgoe, G. S. Pell, D. L. Thomas, M. D. King et al., Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T, Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T Magn, pp.479-85, 1999.
DOI : 10.1002/(SICI)1522-2594(199903)41:3<479::AID-MRM9>3.0.CO;2-2

Y. L. Chan, D. K. Yeung, S. F. Leung, and P. Chan, Diffusion-Weighted Magnetic Resonance Imaging in Radiation-Induced Cerebral Necrosis, Journal of Computer Assisted Tomography, vol.27, issue.5, pp.674-80, 2003.
DOI : 10.1097/00004728-200309000-00003

M. Chatel, M. Frenay, C. Lebrun, V. Bourg, F. Fauchon et al., High grade gliomas: anaplastic astrocytomas and glioblastomas EMC-Neurologie, Radiotherapy of glioblastoma Cancer Radiother, pp.194-207, 1997.

F. A. Dilmanian, Response of avian embryonic brain to spatially segmented x-ray microbeams, Cell Mol. Biol, vol.47, pp.485-93, 2001.

F. A. Dilmanian, Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy, Neuro-Oncology, vol.4, issue.1, pp.26-38, 2002.
DOI : 10.1215/15228517-4-1-26

F. A. Dilmanian, G. M. Morris, N. Zhong, T. Bacarian, J. F. Hainfeld et al., Murine EMT-6 Carcinoma: High Therapeutic Efficacy of Microbeam Radiation Therapy, Radiation Research, vol.159, issue.5, pp.632-673, 2003.
DOI : 10.1667/0033-7587(2003)159[0632:MECHTE]2.0.CO;2

M. Diserbo, A. Agin, L. Lamproglou, J. Mauris, F. Staali et al., Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study, Canadian Journal of Physiology and Pharmacology, vol.80, issue.7, pp.670-678, 2002.
DOI : 10.1139/y02-070

P. P. Fatouros and A. Marmarou, Use of magnetic resonance imaging for in vivo measurements of water content in human brain: method and normal values, Journal of Neurosurgery, vol.90, issue.1, pp.109-124, 1999.
DOI : 10.3171/jns.1999.90.1.0109

K. Hitschke, R. Buhler, H. J. Apell, and G. Stark, ATPase by radiation-induced free radicals. Evidence for a radical-chain mechanism FEBS Lett, pp.297-300, 1994.

J. Ito, A. Marmarou, P. Barzo, P. Fatouros, and C. F. , Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury, Journal of Neurosurgery, vol.84, issue.1, pp.97-103, 1996.
DOI : 10.3171/jns.1996.84.1.0097

J. A. Laissue, Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays, International Journal of Cancer, vol.14, issue.5, pp.654-60, 1998.
DOI : 10.1002/(SICI)1097-0215(19981123)78:5<654::AID-IJC21>3.0.CO;2-L

J. A. Laissue, The weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy, pediatric neuro-oncology Proc. of SPIE, pp.65-73, 2001.

T. Loenneker, K. H. Adcock, K. A. Il-'yasov, and E. Martin, Unbiased determination of the brain infarction size using diffusion-weighted MRI: validation in rats with transient hemispheric cerebral hypoxia?ischemia Magn, Reson. Mat. Phys. Med. Biol, pp.18-221, 2005.

A. Marmarou, W. Poll, K. Shulman, and H. Bhagavan, A simple gravimetric technique for measurement of cerebral edema, Journal of Neurosurgery, vol.49, issue.4, pp.530-537, 1978.
DOI : 10.3171/jns.1978.49.4.0530

A. Marmarou, Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients, Journal of Neurosurgery, vol.93, issue.2, pp.183-93, 2000.
DOI : 10.3171/jns.2000.93.2.0183

A. Marmarou, G. Portella, P. Barzò, S. Signoretti, P. Fatouros et al., Distinguishing between cellular and vasogenic edema in head-injured patients with focal lesions using MRI Acta Neurochir, pp.349-51, 2000.

A. Marmarou, K. Tanaka, and K. Shulman, An improved gravimetric measure of cerebral edema, Journal of Neurosurgery, vol.56, issue.2, pp.246-53, 1982.
DOI : 10.3171/jns.1982.56.2.0246

M. Miura, H. Blattmann, E. Brauer-krisch, A. Bravin, A. L. Hanson et al., Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams, The British Journal of Radiology, vol.79, issue.937, pp.71-76, 2006.
DOI : 10.1259/bjr/50464795

R. Moretti, P. Torre, R. M. Antonello, T. Cattaruzza, G. Cazzato et al., Neuropsychological evaluation of late-onset post-radiotherapy encephalopathy: a comparison with vascular dementia, Journal of the Neurological Sciences, vol.229, issue.230, pp.229-230, 2005.
DOI : 10.1016/j.jns.2004.11.027

H. Nakata, T. Yoshimine, A. Murasawa, E. Kumura, and K. Harada, Early blood-brain barrier disruption after high-dose single-fraction irradiation in rats, Acta Neurochirurgica, vol.57, issue.1-2, pp.82-88
DOI : 10.1007/BF01411440

S. Naruse, Y. Horikawa, C. Tanaka, K. Hirakawa, H. Nishikawa et al., Proton nuclear magnetic resonance studies on brain edema, Proton nuclear magnetic resonance studies, pp.747-52, 1982.
DOI : 10.3171/jns.1982.56.6.0747

W. Ng, Radiation associated changes in tissues and tumors Curr, Diagn. Pathol, vol.9, pp.124-160, 2003.

J. F. Payen, B. Fauvage, D. Falcon, and P. Lavagne, ??d??me c??r??bral par l??sion de la barri??re h??matoenc??phalique : m??canismes et diagnostic, Annales Fran??aises d'Anesth??sie et de R??animation, vol.22, issue.3, pp.220-225, 2003.
DOI : 10.1016/S0750-7658(03)00010-8

P. R. Rau, J. Sellner, S. Heiland, K. Plaschke, P. D. Schellinger et al., Apparent diffusion coefficient in the aging mouse brain: A magnetic resonance imaging study, Life Sciences, vol.78, issue.11, pp.1175-80, 2006.
DOI : 10.1016/j.lfs.2005.06.032

G. Schlaug, B. Siewert, A. Benfield, R. Edelman, and S. Warach, Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke, Neurology, vol.49, issue.1, pp.113-122, 1997.
DOI : 10.1212/WNL.49.1.113

P. M. Schweizer, P. Spanne, D. Michiel, M. Jauch, U. Blattmann et al., Tissue lesions caused by microplanar beams of synchrotron-generated X-rays in Drosophila melanogaster, Int. J. Radiat. Biol, vol.76, pp.567-74, 2000.

R. Serduc, In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.5, pp.1519-1546, 2006.
DOI : 10.1016/j.ijrobp.2005.11.047

URL : https://hal.archives-ouvertes.fr/inserm-00388979

E. A. Siegbahn, J. Stepanek, E. Bräuer-krisch, and A. Bravin, Determination of dosimetrical quantities used in microbeam radiation therapy (MRT) with Monte Carlo simulations Med. Phys, pp.3248-59, 2006.

A. Skowronska-gardas, K. Pedziwiatr, and M. Chojnacka, Evaluation of quality of life in long-term survivors of paediatric brain stem tumors, treated with radiotherapy Radiother, Oncol, vol.70, pp.269-73, 2004.

H. Smilowitz, Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas, Journal of Neuro-Oncology, vol.64, issue.064303, pp.135-178, 2006.
DOI : 10.1007/s11060-005-9094-9

C. Sotak, The role of diffusion tensor imaging in the evaluation of ischemic brain injury?a review NMR Biomed, pp.561-570, 2002.

S. George, E. J. Kudhail, J. Perks, J. Plowman, and P. , Acute symptoms after gamma knife radiosurgery, J. Neurosurg, vol.97, pp.631-635, 2002.

E. Stejskal and J. Tanner, Spin Diffusion Measurements: Spin Echoes in the Presence of a Time???Dependent Field Gradient, The Journal of Chemical Physics, vol.42, issue.1, pp.288-92, 1965.
DOI : 10.1063/1.1695690

G. T. Szeifert, N. Massager, D. Devriendt, P. David, D. Smedt et al., Observations of intracranial neoplasms treated with gamma knife radiosurgery, J. Neurosurg, vol.97, pp.623-629, 2002.

H. Takagi, K. Shapiro, A. Marmarou, and H. Wisoff, Microgravimetric analysis of human brain tissue Correlation with computerized tomography scanning, Journal of Neurosurgery, vol.54, issue.6, pp.797-801, 1981.
DOI : 10.3171/jns.1981.54.6.0797

Y. Tian, S. Bao, C. Liu, and W. Yin, Early changes in regional cerebral blood flow and water content following irradiation to rat brain, Chin. Med. J, vol.114, pp.30-39, 2001.

A. A. Toogood, Endocrine consequences of brain irradiation, Growth Hormone & IGF Research, vol.14, pp.118-142, 2004.
DOI : 10.1016/j.ghir.2004.03.038

A. Tosoni, M. Ermani, and A. A. Brandes, The pathogenesis and treatment of brain metastases: a comprehensive review, Critical Reviews in Oncology/Hematology, vol.52, issue.3, pp.199-215, 2004.
DOI : 10.1016/j.critrevonc.2004.08.006

Y. Van-de-looij, H. Lahrech, G. Francony, O. Carle, R. Farion et al., Early MRI characterization of cerebral edema following diffuse traumatic brain injury in rat Int, Society for Magnetic Resonance in Medicine, 2006.

M. Van-vulpen, H. B. Kal, M. J. Taphoorn, and S. El-sharouni, Changes in blood-brain barrier permeability induced by radiotherapy: Implications for timing of chemotherapy? (Review), Oncology Reports, vol.9, pp.683-691, 2002.
DOI : 10.3892/or.9.4.683

K. M. Welch, J. Windham, R. A. Knight, V. Nagesh, J. W. Hugg et al., A Model to Predict the Histopathology of Human Stroke Using Diffusion and T2-Weighted Magnetic Resonance Imaging, Stroke, vol.26, issue.11, pp.1983-1992, 1995.
DOI : 10.1161/01.STR.26.11.1983

M. Werner-wasik, S. Rudoler, P. E. Preston, W. W. Hauck, B. M. Downes et al., Immediate side effects of stereotactic radiotherapy and radiosurgery, International Journal of Radiation Oncology*Biology*Physics, vol.43, issue.2, pp.299-304, 1999.
DOI : 10.1016/S0360-3016(98)00410-6

H. Yuan, M. W. Gaber, T. Mccolgan, M. D. Naimark, M. F. Kiani et al., Radiation-induced permeability and leukocyte adhesion in the rat blood???brain barrier: modulation with anti-ICAM-1 antibodies, Brain Research, vol.969, issue.1-2, pp.59-69, 2003.
DOI : 10.1016/S0006-8993(03)02278-9

N. Zhong, G. M. Morris, T. Bacarian, E. Rosen, and F. A. Dilmanian, Response of Rat Skin to High-Dose Unidirectional X-Ray Microbeams: A Histological Study, Radiation Research, vol.160, issue.2, pp.133-175, 2003.
DOI : 10.1667/3033