P. Ahonen, S. Myllarniemi, I. Sipila, and J. Perheentupa, Clinical Variation of Autoimmune Polyendocrinopathy???Candidiasis???Ectodermal Dystrophy (APECED) in a Series of 68 Patients, New England Journal of Medicine, vol.322, issue.26, pp.1829-1865, 1990.
DOI : 10.1056/NEJM199006283222601

M. Anderson, E. Venanzi, and L. Klein, Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein, Science, vol.298, issue.5597, pp.1395-401, 2002.
DOI : 10.1126/science.1075958

M. Alimohammadi, P. Björklund, and Å. Hallgren, Autoimmune Polyendocrine Syndrome Type 1 and NALP5, a Parathyroid Autoantigen, New England Journal of Medicine, vol.358, issue.10, pp.1018-1046, 2008.
DOI : 10.1056/NEJMoa0706487

O. Ekwall, H. Hedstrand, and L. Grimelius, Identification of tryptophan hydroxylase as an intestinal autoantigen, The Lancet, vol.352, issue.9124, pp.279-83, 1998.
DOI : 10.1016/S0140-6736(97)11050-9

O. Winqvist, F. Karlsson, and O. Kämpe, 21-hydroxylase, a major autoantigen in idiopathic Addison's disease, The Lancet, vol.339, issue.8809, pp.1559-62, 1992.
DOI : 10.1016/0140-6736(92)91829-W

C. Betterle, D. Pra, C. Mantero, F. Zanchetta, and R. , Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction, Endocrine Reviews, vol.23, issue.3, pp.327-64, 2002.
DOI : 10.1210/edrv.23.3.0466

M. Neufeld, N. Maclaren, and R. Blizzard, Autoimmune Polyglandular Syndromes, Pediatric Annals, vol.9, issue.4, pp.154-62, 1980.
DOI : 10.3928/0090-4481-19800401-07

M. Gylling, T. Tuomi, and P. Björses, ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasisectodermal dystrophy, J Clin Endocrinol Metab, vol.85, issue.12, pp.4434-4474, 2000.

W. Jiang, M. Anderson, R. Bronson, D. Mathis, and C. Benoist, Modifier loci condition autoimmunity provoked by Aire deficiency, The Journal of Experimental Medicine, vol.162, issue.6, pp.805-820, 2005.
DOI : 10.2337/diabetes.52.3.882

D. Luca, F. Valenzise, M. Alaggio, and R. , Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers, Eur J Pediatr, 2008.

J. Perheentupa, Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, The Journal of Clinical Endocrinology & Metabolism, vol.91, issue.8, pp.2843-50, 2006.
DOI : 10.1210/jc.2005-2611

F. Rorsman, E. Husebye, O. Winqvist, E. Björk, F. Karlsson et al., Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen., Proceedings of the National Academy of Sciences, vol.92, issue.19, pp.8626-8635, 1995.
DOI : 10.1073/pnas.92.19.8626

S. Altschul, T. Madden, and A. Schaffer, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-402, 1997.
DOI : 10.1093/nar/25.17.3389

E. Husebye, G. Gebre-medhin, and T. Tuomi, Autoantibodies against aromatic Lamino acid decarboxylase in autoimmune polyendocrine syndrome type I, J Clin Endocrinol Metab, vol.82, issue.1, pp.147-50, 1997.

A. Falorni, A. Nikoshkov, and S. Laureti, High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase, J Clin Endocrinol Metab, vol.80, issue.9, pp.2752-2757, 1995.

A. Falorni, E. Örtqvist, B. Persson, and A. Lernmark, Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands, Journal of Immunological Methods, vol.186, issue.1, pp.89-99, 1995.
DOI : 10.1016/0022-1759(95)00139-2

O. Shmueli, S. Horn-saban, and V. Chalifa-caspi, GeneNote: whole genome expression profiles in normal human tissues, Comptes Rendus Biologies, vol.326, issue.10-11, pp.10-111067, 2003.
DOI : 10.1016/j.crvi.2003.09.012

A. Su, M. Cooke, and K. Ching, Large-scale analysis of the human and mouse transcriptomes, Proceedings of the National Academy of Sciences, vol.99, issue.7, pp.4465-70, 2002.
DOI : 10.1073/pnas.012025199

URL : https://hal.archives-ouvertes.fr/hal-00311329

O. Ekwall, K. Sjöberg, R. Mirakian, F. Rorsman, and O. Kämpe, Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type 1, The Lancet, vol.354, issue.9178, p.568, 1999.
DOI : 10.1016/S0140-6736(99)01989-3

H. Hedstrand, O. Ekwall, and M. Olsson, The Transcription Factors SOX9 and SOX10 Are Vitiligo Autoantigens in Autoimmune Polyendocrine Syndrome Type I, Journal of Biological Chemistry, vol.276, issue.38, pp.35390-35395, 2001.
DOI : 10.1074/jbc.M102391200

C. Betterle, N. Greggio, and M. Volpato, Autoimmune Polyglandular Syndrome Type 1, The Journal of Clinical Endocrinology & Metabolism, vol.83, issue.4, pp.1049-55, 1998.
DOI : 10.1210/jcem.83.4.4682

D. Ivanov, T. Tyazhelova, and L. Lemonnier, A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14, FEBS Lett, vol.3539, pp.1-3156, 2003.

J. Kidney, J. Lötvall, Y. Lei, K. Chung, and P. Barnes, The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs, European Journal of Pharmacology, vol.296, issue.1, pp.81-88, 1996.
DOI : 10.1016/0014-2999(95)00670-2

R. Small, J. Berry, and R. Foster, Potassium channel opening drugs and the airways, Braz J Med Biol Res, vol.25, issue.10, pp.983-98, 1992.

A. Vincent, Immunology of disorders of neuromuscular transmission, Acta Neurologica Scandinavica, vol.54, issue.s183, pp.1-7, 2006.
DOI : 10.1093/brain/awh077