A. Andrieux, P. A. Salin, and M. Vernet, The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders, Genes & Development, vol.16, issue.18, pp.2350-2364, 2002.
DOI : 10.1101/gad.223302

R. Bartha, Y. M. Semaan, and P. C. Williamson, A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients, Biological Psychiatry, vol.45, issue.11, pp.1403-1411, 1999.
DOI : 10.1016/S0006-3223(99)00007-4

M. H. Baslow, Brain N-Acetylaspartate as a Molecular Water Pump and its Role in the Etiology of Canavan Disease: A Mechanistic Explanation, Journal of Molecular Neuroscience, vol.21, issue.3, pp.185-90, 2003.
DOI : 10.1385/JMN:21:3:185

S. Berl and D. D. Clarke, The metabolic compartmentation concept, in Glutamine, Glutamate and GABA in The Central Nervous System, pp.205-217, 1983.

E. Brenner, D. Kondziella, A. Haberg, and U. Sonnewald, Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801, Journal of Neurochemistry, vol.41, issue.6, pp.1594-1603, 2005.
DOI : 10.1023/A:1021636102735

P. Brun, M. Bégou, and A. Andrieux, Dopaminergic transmission in STOP null mice, Journal of Neurochemistry, vol.65, issue.1, pp.63-73, 2005.
DOI : 10.1016/0165-0173(90)90015-G

URL : https://hal.archives-ouvertes.fr/inserm-00380189

M. Carlsson, A. Carlsson, and M. Nilsson, Schizophrenia: From Dopamine to Glutamate and Back, Current Medicinal Chemistry, vol.11, issue.3, pp.267-277, 2004.
DOI : 10.2174/0929867043456034

A. Carlsson, N. Waters, and S. Holm-waters, : New Evidence, Annual Review of Pharmacology and Toxicology, vol.41, issue.1, pp.237-260, 2001.
DOI : 10.1146/annurev.pharmtox.41.1.237

S. I. Deutsch, R. B. Rosse, B. L. Schwartz, and J. Mastropaolo, A Revised Excitotoxic Hypothesis of Schizophrenia: Therapeutic Implications, Clinical Neuropharmacology, vol.24, issue.1, pp.43-49, 2001.
DOI : 10.1097/00002826-200101000-00008

E. M. Eyjolfsson, E. Brenner, D. Kondziella, and U. Sonnewald, Repeated injection of MK801: An animal model of schizophrenia?, Neurochemistry International, vol.48, issue.6-7, pp.541-546, 2006.
DOI : 10.1016/j.neuint.2005.11.019

K. J. Friston, Dysfunctional connectivity in schizophrenia, World Psychiat, vol.1, pp.66-71, 2002.

M. R. Galiano, C. Bosc, and A. Schweitzer, Astrocytes and oligodendrocytes express different STOP protein isoforms, Journal of Neuroscience Research, vol.19, issue.3, pp.329-337, 2004.
DOI : 10.1002/jnr.20260

J. W. Geddes and J. D. Wood, Changes in the Amino Acid Content of Nerve Endings (Synaptosomes) Induced by Drugs that Alter the Metabolism of Glutamate and ?-Aminobutyric Acid, Journal of Neurochemistry, vol.37, issue.1, pp.16-24, 1984.
DOI : 10.1016/0020-711X(81)90178-6

A. Halberstadt, The Phencyclidine-Glutamate Model of Schizophrenia, Clinical Neuropharmacology, vol.18, issue.3, pp.237-249, 1995.
DOI : 10.1097/00002826-199506000-00004

P. J. Harrison, The neuropathology of schizophrenia: A critical review of the data and their interpretation, Brain, vol.122, issue.4, pp.593-624, 1999.
DOI : 10.1093/brain/122.4.593

L. S. Kegeles, A. Abi-dargham, and Y. Zea-ponce, Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia, Biological Psychiatry, vol.48, issue.7, pp.627-640, 2000.
DOI : 10.1016/S0006-3223(00)00976-8

D. Kondziella, E. Brenner, and E. M. Eyjolfsson, Glial???Neuronal Interactions are Impaired in the Schizophrenia Model of Repeated MK801 Exposure, Neuropsychopharmacology, vol.5, issue.9, 2005.
DOI : 10.1038/sj.npp.1300993

E. Kosenko, M. Llansola, and C. Montoliu, Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide, Neurochemistry International, vol.43, issue.4-5, pp.493-499, 2003.
DOI : 10.1016/S0197-0186(03)00039-1

A. C. Lahti, B. Koffel, D. Laporte, and C. A. Tamminga, Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia, Neuropsychopharmacology, vol.13, issue.1, pp.9-19, 1995.
DOI : 10.1016/0893-133X(94)00131-I

V. Lebon, K. F. Petersen, and G. W. Cline, Astroglial contribution to brain energy metabolism in humans revealed by 13 C nuclear magnetic resonance spectroscopy. Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism, J. Neurosci, vol.22, pp.1523-1531, 2002.

S. Marenco and D. R. Weinberger, The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave, Development and Psychopathology, vol.12, issue.3, pp.501-527, 2000.
DOI : 10.1017/S0954579400003138

T. M. Melo, A. Nehlig, and U. Sonnewald, Neuronal???glial interactions in rats fed a ketogenic diet, Neurochemistry International, vol.48, issue.6-7, pp.498-507, 2006.
DOI : 10.1016/j.neuint.2005.12.037

D. W. Miller and E. D. Abercrombie, Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats, Brain Research Bulletin, vol.40, issue.1, pp.57-62, 1996.
DOI : 10.1016/0361-9230(95)02144-2

K. Mirnics, F. A. Middleton, D. A. Lewis, and P. Levitt, Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse, Trends in Neurosciences, vol.24, issue.8, pp.479-486, 2001.
DOI : 10.1016/S0166-2236(00)01862-2

D. D. Murphy, N. B. Cole, V. Greenberger, and M. Segal, Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons, J. Neurosci, vol.18, pp.2550-2559, 1998.

M. D. Norenberg and A. Martinez-hernandez, Fine structural localization of glutamine synthetase in astrocytes of rat brain, Brain Research, vol.161, issue.2, pp.303-310, 1979.
DOI : 10.1016/0006-8993(79)90071-4

J. W. Olney and N. B. Farber, Glutamate Receptor Dysfunction and Schizophrenia, Archives of General Psychiatry, vol.52, issue.12, pp.998-1007, 1995.
DOI : 10.1001/archpsyc.1995.03950240016004

O. P. Ottersen and J. Storm-mathisen, Excitatory Amino Acid Pathways in the Brain, Adv. Exp. Med. Biol, vol.203, pp.263-84, 1986.
DOI : 10.1007/978-1-4684-7971-3_20

G. Palaiologos, A. Schousboe, and L. Hertz, Evidence that Aspartate Aminotransferase Activity and Ketodicarboxylate Carrier Function Are Essential for Biosynthesis of Transmitter Glutamate, Journal of Neurochemistry, vol.42, issue.1, pp.317-337, 1988.
DOI : 10.1016/0165-3806(82)90091-8

H. Qu, A. Haberg, and O. Haraldseth, <sup>13</sup>C MR Spectroscopy Study of Lactate as Substrate for Rat Brain, Developmental Neuroscience, vol.22, issue.5-6, pp.429-436, 2000.
DOI : 10.1159/000017472

P. Seeman, Dopamine receptors and the dopamine hypothesis of schizophrenia, Synapse, vol.54, issue.2, pp.133-152, 1987.
DOI : 10.1002/syn.890010203

R. P. Shank, G. S. Bennett, S. O. Freytag, and G. L. Campbell, Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acids neurotransmitter pool, Brain Res, vol.329, pp.362-367, 1985.

R. G. Shulman, D. L. Rothman, K. L. Behar, and F. Hyder, Energetic basis of brain activity: implications for neuroimaging, Trends in Neurosciences, vol.27, issue.8, pp.489-495, 2004.
DOI : 10.1016/j.tins.2004.06.005

N. R. Sibson, G. F. Mason, and J. Shen, In vivo13C???NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2-13C]glucose infusion, Journal of Neurochemistry, vol.66, issue.4, pp.975-989, 2001.
DOI : 10.1046/j.1471-4159.2001.00074.x

U. Sonnewald and D. Kondziella, Neuronal glial interaction in different neurological diseases studied byex vivo13C NMR spectroscopy, NMR in Biomedicine, vol.16, issue.67, pp.424-429, 2003.
DOI : 10.1002/nbm.837

U. Sonnewald, G. Therrien, and R. F. Butterworth, Portacaval Anastomosis Results in Altered Neuron-Astrocytic Metabolic Trafficking of Amino Acids: Evidence from 13C-NMR Studies, Journal of Neurochemistry, vol.67, issue.4, pp.1711-1717, 1996.
DOI : 10.1046/j.1471-4159.1996.67041711.x

U. Sonnewald, N. Westergaard, and A. Schousboe, Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons, Neurochemistry International, vol.22, issue.1, pp.19-29, 1993.
DOI : 10.1016/0197-0186(93)90064-C

J. Theberge, Y. Al-semaan, and P. C. Williamson, Glutamate and Glutamine in the Anterior Cingulate and Thalamus of Medicated Patients With Chronic Schizophrenia and Healthy Comparison Subjects Measured With 4.0-T Proton MRS, American Journal of Psychiatry, vol.160, issue.12, pp.2231-2233, 2003.
DOI : 10.1176/appi.ajp.160.12.2231

J. Theberge, R. Bartha, and D. J. Drost, Glutamate and Glutamine Measured With 4.0 T Proton MRS in Never-Treated Patients With Schizophrenia and Healthy Volunteers, American Journal of Psychiatry, vol.159, issue.11, pp.1944-1946, 2002.
DOI : 10.1176/appi.ajp.159.11.1944

R. A. Waniewski and D. L. Martin, Preferential utilization of acetate by astrocytes is attributable to transport, J. Neurosci, vol.18, pp.5225-5233, 1998.