PMID: identifiant
de la référence Pubmed : |
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 (19064650)  |
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| titre : |
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Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. |
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| auteur(s) : |
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Virginie Rondeau ( ) 1, Hélène Jacqmin-Gadda1, Daniel Commenges1, Catherine Helmer1, 2, Jean-François Dartigues1, 2 |
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| laboratoire : |
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| résumé : |
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The authors examined associations between exposure to aluminum or silica from drinking water and risk of cognitive decline, dementia, and Alzheimer's disease among elderly subjects followed for 15 years (1988-2003). They actively searched for incident cases of dementia among persons aged 65 years or over living in 91 civil drinking-water areas in southern France. Two measures of exposure to aluminum were assessed: geographic exposure and individual exposure, taking into account daily consumption of tap water and bottled water. A total of 1,925 subjects who were free of dementia at baseline and had reliable water assessment data were analyzed. Using random-effects models, the authors found that cognitive decline with time was greater in subjects with a higher daily intake of aluminum from drinking water (>or=0.1 mg/day, P=0.005) or higher geographic exposure to aluminum. Using a Cox model, a high daily intake of aluminum was significantly associated with increased risk of dementia. Conversely, an increase of 10 mg/day in silica intake was associated with a reduced risk of dementia (adjusted relative risk =0.89, P=0.036). However, geographic exposure to aluminum or silica from tap water was not associated with dementia. High consumption of aluminum from drinking water may be a risk factor for Alzheimer's disease. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1476-6256 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1093/aje/kwn348 |
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| journal : |
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| Audience : |
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internationale |
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| date de publication : |
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15/02/2009 |
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date de publication
électronique : |
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08/12/2008 |
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| volume : |
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169 |
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| numéro : |
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4 |
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| page, identifiant, ... : |
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489-96 |
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| Descripteur(s) MeSH : |
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Aged – 80 and over – Aluminum – Alzheimer Disease – Cognition Disorders – Drinking – Environmental Exposure – Female – Follow-Up Studies – France – Humans – Incidence – Male – Proportional Hazards Models – Psychiatric Status Rating Scales – Questionnaires – Rural Population – Silicon Dioxide – Urban Population – Water Pollutants – Chemical – Water Supply |
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