PMID: identifiant
de la référence Pubmed : |
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 (19017688)  |
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| titre : |
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Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study. |
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| auteur(s) : |
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Laurent Orsi ( ) 1, Laurene Delabre2, Alain Monnereau1, 3, 4, Philippe Delval5, Christian Berthou6, Pierre Fenaux7, Gerald Marit8, Pierre Soubeyran3, Francoise Huguet9, Noel Milpied8, Michel Leporrier10, Denis Hemon1, Xavier Troussard11, Jacqueline Clavel1 |
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| laboratoire : |
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| résumé : |
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OBJECTIVES: Investigating the relationship between occupational exposure to pesticides and the risk of lymphoid neoplasms (LNs) in men. METHODS: A hospital-based case-control study was conducted in six centres in France between 2000 and 2004. The cases were incident cases with a diagnosis of LN aged 18-75 years. During the same period, controls of the same age and sex as the cases were recruited in the same hospital, mainly in the orthopaedic and rheumatological departments. Exposures to pesticides were evaluated through specific interviews and case-by-case expert reviews. Four hundred and ninety-one cases (244 cases of non-Hodgkin's lymphoma (NHL), 87 of Hodgkin's lymphoma (HL), 104 of lymphoproliferative syndromes (LPSs) and 56 of multiple myeloma (MM) cases) and 456 controls were included in the analyses. The odds ratios (ORs) and 95% CI were estimated using unconditional logistic regressions. RESULTS: Positive associations between HL and occupational exposure to triazole fungicides and urea herbicides were observed (OR = 8.4 (2.2 to 32.4), 10.8 (2.4 to 48.1), respectively). Exposure to insecticides, fungicides and herbicides were linked to a threefold increase in MM risk (OR = 2.8 (1.2 to 6.5), 3.2 (1.4 to 7.2), 2.9 (1.3 to 6.5)). For LPS subtypes, associations restricted to hairy-cell leukaemia (HCL) were evidenced for exposure to organochlorine insecticides, phenoxy herbicides and triazine herbicides (OR = 4.9 (1.1 to 21.2), 4.1 (1.1 to 15.5), 5.1 (1.4 to 19.3)), although based on small numbers. Lastly, despite the increased ORs for organochlorine and organophosphate insecticides, carbamate fungicides and triazine herbicides, no significant associations were evidenced for NHL. CONCLUSIONS: The results, based on case-by-case expert review of occupation-specific questionnaires, support the hypothesis that occupational pesticide exposures may be involved in HL, MM and HCL and do not rule out a role in NHL. The analyses identified specific pesticides that deserve further investigation and the findings were consistent with those of previous studies. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1470-7926 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1136/oem.2008.040972 |
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| journal : |
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Occup Environ Med |
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| Audience : |
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internationale |
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| date de publication : |
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05/2009 |
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date de publication
électronique : |
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18/11/2008 |
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| volume : |
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66 |
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| numéro : |
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5 |
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| page, identifiant, ... : |
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291-8 |
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| mots-clés auteur : |
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occupation – pesticides – farming – lymphoma – epidemiology. |
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| Descripteur(s) MeSH : |
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Adolescent – Adult – Aged – Case-Control Studies – Employment – France – Fungicides – Industrial – Herbicides – Hodgkin Disease – Humans – Insecticides – Leukemia – Hairy Cell – Lymphoma – Non-Hodgkin – Male – Middle Aged – Multiple Myeloma – Occupational Diseases – Occupational Exposure – Pesticides – Young Adult |
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