PMID: identifiant
de la référence Pubmed : |
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 (19070973) |
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| titre : |
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The increasing role of amphiregulin in non-small cell lung cancer. |
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| auteur(s) : |
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Benoît Busser1, Jean-Luc Coll1, Amandine Hurbin ( ) 1 |
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| laboratoire : |
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| Équipe de recherche : |
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INSERM U823, équipe 5 (cibles diagnostiques ou thérapeutiques et vectorisation de drogues dans le cancer du poumon) |
| résumé : |
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Non-small cell lung cancers present a 5-year survival rate below 12%. Such a poor prognosis may be explained by non small cell lung cancer cells evasion to apoptosis and resistance to treatments. Amphiregulin, an epidermal growth factor-related growth factor is secreted by non-small cell lung cancer cells in an autocrine/paracrine manner to promote autonomous growth of tumor cells and to provide resistance to apoptosis. Furthermore, amphiregulin is involved in non-small cell lung cancers resistance to epidermal growth factor receptor targeted therapy. This editorial underlines the increasing role of amphiregulin in non-small cell lung cancer cells resistance mechanisms and suggests the use of amphiregulin as a marker for drug sensitivity and/or as a prognostic marker to identify patients that may respond to epidermal growth factor receptor-tyrosine kinase inhibitors. |
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| domaine : |
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Sciences du Vivant/Cancérologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1768-3114 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1016/j.patbio.2008.10.002 |
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| journal : |
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| Pathologie Biologie (Pathol Biol (Paris)) |
| Publisher |
Elsevier |
| ISSN |
0369-8114 |
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| Audience : |
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internationale |
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| date de publication : |
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11/2009 |
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date de publication
électronique : |
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13/12/2008 |
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| volume : |
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57 |
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| numéro : |
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7-8 |
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| page, identifiant, ... : |
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511-2 |
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| mots-clés auteur : |
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amphiregulin – non-small cell lung cancer – gefitinib – growth factor – apoptosis – drug resistance – EGFR – targeted therapy – tyrosine-kinase inhibitors |
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| Descripteur(s) MeSH : |
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Apoptosis – Carcinoma – Non-Small-Cell Lung – Disease Progression – Glycoproteins – Humans – Immunity – Innate – Intercellular Signaling Peptides and Proteins – Lung Neoplasms – Prognosis – Receptor – Epidermal Growth Factor – Tumor Markers – Biological |
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