PMID: identifiant
de la référence Pubmed : |
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 (18519648)  |
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| titre : |
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Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants. |
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| auteur(s) : |
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Sandra Weller1, Maria Mamani-Matsuda1, Capucine Picard2, 3, Corinne Cordier4, Damiana Lecoeuche1, Frédéric Gauthier5, Jean-Claude Weill ( ) 1, Claude-Agnès Reynaud () 1 |
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| laboratoire : |
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| résumé : |
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T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally related. We show that the repertoire of IgM(+)IgD(+)CD27(+) B cells in the spleen and blood displays no sign of antigen-driven activation and expansion on H-CDR3 spectratyping, despite the many antigenic challenges provided by childhood vaccinations. This repertoire differed markedly from those of switched B cells and splenic germinal center B cells, even at the early stage of differentiation associated with mu heavy chain expression. These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses. |
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| domaine : |
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Sciences du Vivant/Immunologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0022-1007 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1084/jem.20071555 |
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| journal : |
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Journal of Experimental Medicine / The Journal of Experimental Medicine |
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| Audience : |
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internationale |
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| date de publication : |
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09/06/2008 |
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date de publication
électronique : |
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02/06/2008 |
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| volume : |
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205 |
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| numéro : |
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6 |
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| page, identifiant, ... : |
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1331-42 |
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| mots-clés auteur : |
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"somatic hypermutation" – "splenic marginal zone" – "Ig repertoire" |
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| Descripteur(s) MeSH : |
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Antigens – CD – Antigens – CD27 – B-Lymphocyte Subsets – B-Lymphocytes – Gene Rearrangement – Humans – Immunoglobulin D – Immunoglobulin M – Immunoglobulin Variable Region – Immunoglobulin mu-Chains – Immunologic Memory – Infant – Lymphocyte Activation – Spleen – T-Lymphocytes – Transcription – Genetic – Variation (Genetics) |
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| contrat, financement : |
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Ligue Nationale contre le Cancer |
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