PMID: identifier of
Pubmed reference: |
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 (18340343) |
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| title: |
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DNA polymerases in adaptive immunity. |
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| author(s): |
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Jean-Claude Weill ( ) 1, Claude-Agnès Reynaud () 1 |
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| laboratory: |
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| 1: |
Developpement du Systeme Immunitaire |
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| INSERM : U783 – Université Paris V - Paris Descartes |
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| Fac de Medecine Necker-Enfants Malades PARIS V 156, Rue de Vaugirard 75730 PARIS CEDEX 15 |
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| France |
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| short title : |
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DNA polymerases in adaptive immunity |
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| abstract: |
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To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key genetic loci in each lymphoid cell. These modifications proceed through the action of lymphoid-specific proteins acting together with the general DNA-repair machinery of the cell. Strikingly, these general mechanisms are usually diverted from their normal functions, being used in rather atypical ways in order to privilege diversity over accuracy. In this Review, we focus on the contribution of a set of DNA polymerases discovered in the past decade to these unique DNA transactions. |
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| subject: |
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Life Sciences/Immunology
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| fulltext language: |
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English |
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| ISSN: |
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1474-1741 |
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| publication format: |
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Article in peer-reviewed journal |
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| DOI: |
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10.1038/nri2281 |
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| journal: |
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Nature reviews in Immunology |
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| Audience: |
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international |
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| publication date: |
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2008-04 |
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| submission date: |
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2008-03-14 |
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| volume: |
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8 |
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| issue: |
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4 |
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| page, identifiant, ...: |
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302-12 |
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| keyword(s) of author: |
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immunoglobulin genes – repertoire – diversity – polymerase |
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| MeSH Descriptor(s): |
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Animals – B-Lymphocytes – DNA-Directed DNA Polymerase – Gene Conversion – Humans – Immunity – Active – Immunoglobulin Class Switching – Somatic Hypermutation – Immunoglobulin |
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| comment: |
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review article |
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