PMID: identifiant
de la référence Pubmed : |
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 (18215437) |
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| titre : |
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Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R. |
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| auteur(s) : |
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Emmanuelle Comets ( ) 1, Karl Brendel2, France Mentré1, 3 |
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| laboratoire : |
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| résumé : |
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Pharmacokinetic/pharmacodynamic data are often analysed using nonlinear mixed-effect models, and model evaluation should be an important part of the analysis. Recently, normalised prediction distribution errors (npde) have been proposed as a model evaluation tool. In this paper, we describe an add-on package for the open source statistical package R, designed to compute npde. npde take into account the full predictive distribution of each individual observation and handle multiple observations within subjects. Under the null hypothesis that the model under scrutiny describes the validation dataset, npde should follow the standard normal distribution. Simulations need to be performed before hand, using for example the software used for model estimation. We illustrate the use of the package with two simulated datasets, one under the true model and one with different parameter values, to show how npde can be used to evaluate models. Model estimation and data simulation were performed using NONMEM version 5.1. |
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| domaine : |
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0169-2607 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1016/j.cmpb.2007.12.002 |
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| journal : |
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| Computer Methods and Programs in Biomedicine (Comput Methods Programs Biomed) |
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Elsevier |
| ISSN |
0169-2607 |
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| Audience : |
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internationale |
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| date de publication : |
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05/2008 |
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date de publication
électronique : |
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22/01/2008 |
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| volume : |
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90 |
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| numéro : |
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2 |
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| page, identifiant, ... : |
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154-66 |
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| mots-clés auteur : |
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Population pharmacokinetics Population pharmacodynamics Model evaluation Nonlinear mixed-effects model npde |
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