Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

Abstract : The World Health Organization estimates that lower respiratory tract infections (excluding tuberculosis) account for approximately 35% of all deaths caused by infectious diseases. In many cases, the cause of death may be caused by multiple pathogens, e.g., the life-threatening bacterial pneumonia observed in patients infected with influenza virus. The ability to evolve more efficient immunity on each successive encounter with antigen is the hallmark of the adaptive immune response. However, in the absence of cross-reactive T and B cell epitopes, one lung infection can modify immunity and pathology to the next for extended periods of time. We now report for the first time that this phenomenon is mediated by a sustained desensitization of lung sentinel cells to Toll-like receptor (TLR) ligands; this is an effect that lasts for several months after resolution of influenza or respiratory syncytial virus infection and is associated with reduced chemokine production and NF-kappaB activation in alveolar macrophages. Although such desensitization may be beneficial in alleviating overall immunopathology, the reduced neutrophil recruitment correlates with heightened bacterial load during secondary respiratory infection. Our data therefore suggests that post-viral desensitization to TLR signals may be one possible contributor to the common secondary bacterial pneumonia associated with pandemic and seasonal influenza infection.
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The Journal of Experimental Medecine, The Rockefeller University Press, 2008, 205 (2), pp.323-9. 〈10.1084/jem.20070891〉
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Contributeur : Jean-Claude Sirard <>
Soumis le : jeudi 31 janvier 2008 - 00:53:43
Dernière modification le : vendredi 19 janvier 2018 - 14:44:02

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Arnaud Didierlaurent, John Goulding, Seema Patel, Robert Snelgrove, Lionel Low, et al.. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.. The Journal of Experimental Medecine, The Rockefeller University Press, 2008, 205 (2), pp.323-9. 〈10.1084/jem.20070891〉. 〈inserm-00227540〉

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