Variation of bispectral index under TIVA with propofol in a paediatric population. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue British Journal of Anaesthesia Année : 2008

Variation of bispectral index under TIVA with propofol in a paediatric population.

Résumé

BACKGROUND: In this prospective observational study, we aim to explore the relationship between age and bispectral index (BIS) values at different plasma concentrations of propofol. METHODS: Fifty children aged from 3 to 15 yr were included. Anaesthesia was induced using a target-controlled infusion of propofol with the Kataria pharmacokinetic model together with a bolus of remifentanil followed by a continuous infusion rate at 0.2 microg kg(-1) min(-1). Target plasma propofol concentration was initially stabilized to 6 microg ml(-1) and continued for 6 min. The target was then decreased and stabilized to 4 microg ml(-1) and then to 2 microg ml(-1). BIS values, plasma propofol concentration, and EEG were continuously recorded. In order to explore the relationship between variations in propofol concentration and the EEG bispectrum, we used a multiple correspondence analysis (MCA). Results are shown in median (range). RESULTS: We found no statistical difference between BIS values with propofol 6 microg ml(-1) [23 (12-40)] and 4 microg ml(-1) [28 (9-67)]. At 2 microg ml(-1), BIS was significantly different [52 (24-71)], but a significant correlation between the age of children and BIS values was found (r2=0.66; P<0.01). There was little change in children's position between 6 and 4 microg ml(-1) in the structure model of the MCA. From 4 to 2 microg ml(-1), the position of children moved only on axis 2. CONCLUSIONS: These results showed the difficulty to interpret BIS values because of the absence of significant change for higher plasma propofol concentration variation or because of the link with age for the lower plasma concentration.
Fichier principal
Vignette du fichier
inserm-00196492_edited.pdf (846.46 Ko) Télécharger le fichier
BIS_Propofol_BJA.pdf (1.64 Mo) Télécharger le fichier
Loading...

Dates et versions

inserm-00196492 , version 1 (11-06-2008)

Identifiants

Citer

Olivier Tirel, Eric Wodey, Rupert Harris, Jean-Yves Bansard, Claude Ecoffey, et al.. Variation of bispectral index under TIVA with propofol in a paediatric population.. British Journal of Anaesthesia, 2008, 100 (1), pp.82-7. ⟨10.1093/bja/aem339⟩. ⟨inserm-00196492⟩
121 Consultations
649 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More