L. B. Sheiner and J. L. Steimer, Pharmacokinetic/Pharmacodynamic Modeling in Drug Development, Annual Review of Pharmacology and Toxicology, vol.40, issue.1, pp.67-95, 2000.
DOI : 10.1146/annurev.pharmtox.40.1.67

L. Aarons, M. O. Karlsson, F. Mentre, F. Rombout, J. L. Steimer et al., Role of modelling and simulation in Phase I drug development, European Journal of Pharmaceutical Sciences, vol.13, issue.2, pp.115-122, 2001.
DOI : 10.1016/S0928-0987(01)00096-3

3. R. Jochemsen, C. Laveille, and D. D. Breimer, Application of pharmacokinetic/pharmacodynamic modelling and population approaches to drug development, International J. of Pharmaceutical Medicine, vol.13, pp.243-251, 1999.

L. J. Lesko, M. Rowland, C. C. Peck, and T. F. Blaschke, Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans, Pharmaceutical Research, vol.17, issue.11, pp.1335-1344, 2000.
DOI : 10.1023/A:1007574217260

H. C. Kimko and S. B. , Simulation for designing clinical trials: a pharmacokineticpharmacodynamic modeling prospective, 2003.

D. Food and . Administration, Guidance for Industry: population pharmacokinetics, 1999.

E. I. Ette, Stability and Performance of a Population Pharmacokinetic Model, The Journal of Clinical Pharmacology, vol.87, issue.6, pp.486-495, 1997.
DOI : 10.1002/j.1552-4604.1997.tb04326.x

P. J. Williams, E. I. Ette-yano, S. L. Beal, and L. B. Sheiner, Determination of model appropriateness Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check, J. Pharmacokinet. Pharmacodyn, vol.2801, issue.10, pp.171-0406, 2003.

E. Comets, K. Ikeda, P. Hoff, P. Fumoleau, J. Wanders et al., Comparison of the Pharmacokinetics of S-1, an Oral Anticancer Agent, in Western and Japanese Patients, Journal of Pharmacokinetics and Pharmacodynamics, vol.30, issue.4, pp.257-283, 2003.
DOI : 10.1023/A:1026142601822

URL : https://hal.archives-ouvertes.fr/inserm-00189555

S. L. Beal, Ways to fit a PK model with some data below the quantification limit, Journal of Pharmacokinetics and Pharmacodynamics, vol.28, issue.5, pp.481-504, 2001.
DOI : 10.1023/A:1012299115260

P. Delrat, M. Paraire, and R. Jochemsen, Complete bioavailability and lack of food-effect on pharmacokinetics of gliclazide 30 mg modified release in healthy volunteers, Biopharmaceutics & Drug Disposition, vol.6, issue.4, pp.151-157, 2002.
DOI : 10.1002/bdd.303

R. J. Simes, An improved Bonferroni procedure for multiple tests of significance, Biometrika, vol.73, issue.3, pp.751-764, 1986.
DOI : 10.1093/biomet/73.3.751

S. L. Beal and L. B. Sheiner, NONMEM Users Guides (I-VIII), Globomax LLC, 1989.

F. Mesnil, F. Mentré, C. Dubruc, J. P. Thenot, and A. Mallet, Population pharmacokinetic analysis of mizolastine and validation from sparse data on patients using the nonparametric maximum likelihood method, Journal of Pharmacokinetics and Biopharmaceutics, vol.26, issue.2, pp.133-161, 1998.
DOI : 10.1023/A:1020505722924

E. Comets and F. Mentré, EVALUATION OF TESTS BASED ON INDIVIDUAL VERSUS POPULATION MODELING TO COMPARE DISSOLUTION CURVES, Journal of Biopharmaceutical Statistics, vol.11, issue.3, pp.107-123, 2001.
DOI : 10.1081/BIP-100107652

F. Mentré and M. E. Ebelin, Validation of population pharmacokinetic/pharmacodynamic analyses: review of proposed approaches. The population approach: measuring and 04, p.6

A. Gelman, J. B. Carlin, H. S. Stern, and R. D. , Bayesian data analysis, 1995.

A. Hooker and M. O. Karlsson, Conditional weighted residuals. A diagnostic to improve population PK/PD model building and evaluation, AAPS J, vol.7, issue.S2, p.5321, 2005.

M. J. Bayarri, P. M. Bergerj, A. Robins, V. Van-der-vaart, and . Ventura, P values for composite null models Assymptotic distribution of P values in composite null models, JASA. JASA, vol.95, issue.95, pp.1143-11721143, 2000.

J. M. Robins, A. Van-der-vaart, V. Venturag, E. Verbecke, and . Lesaffre, Assymptotic distribution of P values in composite null models A linear mixed-effects models with heterogeneity in random effects population, JASA. JASA, vol.95, issue.91, pp.1143-1172217, 1996.

G. Verbecke and E. Lesaffre, A Linear Mixed-Effects Model with Heterogeneity in the Random-Effects Population, Journal of the American Statistical Association, vol.86, issue.433, pp.217-221, 1996.
DOI : 10.1080/01621459.1989.10478736