Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines.
Résumé
Novel 1,4-benzodiazepine compounds were synthesized and evaluated for their ability to inhibit the proliferation of tumor cells. Some compounds revealed activities in the micromolar range and were more efficient than reference compound Ro 5-4864. Preliminary SAR helped to identify critical motifs for antiproliferative activity and led to the discovery of a compound selective for a melanoma cell line, known for its resistance to chemotherapy.
Domaines
Sciences pharmaceutiques
Fichier principal
revised_manuscript_2_.pdf (116.54 Ko)
Télécharger le fichier
Graphical_Abstract.pdf (13.28 Ko)
Télécharger le fichier
Loading...