TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Cellular Signalling Année : 2004

TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression.

Résumé

The balance between production and degradation of type I collagen plays a critical role in the development and maintenance of organ and tissue integrity. It also represents the most crucial element governing the process of tissue repair. The synthesis of type I collagen gene is highly regulated by different cytokines at the transcriptional level. Especially, transforming growth factor beta (TGF-beta), a key player in the physiopathology of tissue repair, enhances type I collagen gene expression. In contrast, tumor necrosis factor alpha (TNF-alpha), whose matrix-remodelling function is opposite to that of TGF-beta, reduces type I collagen gene expression. This review focuses on transcriptional regulation of type I collagen by TGF-beta and TNF-alpha and on the molecular mechanisms that control the antagonistic activity of TNF-alpha against TGF-beta-driven type I collagen gene expression.

Domaines

Cancer
Fichier principal
Vignette du fichier
Verrecchia_et_al.pdf (249.03 Ko) Télécharger le fichier
Loading...

Dates et versions

inserm-00147459 , version 1 (21-05-2007)

Identifiants

Citer

Franck Verrecchia, Alain Mauviel. TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression.. Cellular Signalling, 2004, 16 (8), pp.873-80. ⟨10.1016/j.cellsig.2004.02.007⟩. ⟨inserm-00147459⟩

Collections

INSERM
84 Consultations
1108 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More