Tumor necrosis factor is a survival and proliferation factor for human myeloma cells. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue European Cytokine Network Année : 1999

Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.

Résumé

Interleukin-6 (IL-6) is a major survival factor for malignant plasma cells. In patients with multiple myeloma (MM), cell lines whose survival and proliferation are dependent upon addition of exogenous IL-6 have been obtained. We show here that tumor necrosis factor-alpha (TNF-alpha) is also a survival factor for myeloma cell lines, although less potent than IL-6. The survival activity of TNF-alpha is not affected by anti-IL-6 or anti-gp130 monoclonal antibodies (mAbs). TNF-alpha also induces myeloma cells in the cell cycle and promotes the long-term growth of malignant plasma cell lines. As TNF-alpha is produced in patients with MM and associated with a poor prognosis, these results suggest that anti-TNF-alpha therapies could be useful in this disease.
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Dates et versions

inserm-00142273 , version 1 (18-04-2007)

Identifiants

  • HAL Id : inserm-00142273 , version 1
  • PUBMED : 10210775

Citer

Michel Jourdan, Karin Tarte, Eric Legouffe, Jean Brochier, Jean-François Rossi, et al.. Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.. European Cytokine Network, 1999, 10 (1), pp.65-70. ⟨inserm-00142273⟩
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