PMID: identifiant
de la référence Pubmed : |
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 (16373378)  |
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| titre : |
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Weight change and changes in the metabolic syndrome as the French population moves towards overweight: the D.E.S.I.R. cohort. |
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| auteur(s) : |
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Teresa Hillier1, Anne Fagot-Campagna2, Eveline Eschwège1, S. Vol3, Martine Cailleau3, Beverley Balkau ( ) 1, DESIR cohort Collaboration(s) |
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| laboratoire : |
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| Équipe de recherche : |
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nutrition obesite diabete rein (NODR) |
| titre abrégé : |
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T. Hillier et al: Weight Gain and the metabolic syndrome |
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| résumé : |
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BACKGROUND: How weight change affects the metabolic syndrome (MS) and its parameters is unknown, particularly, in a leaner European population such as the French prospective D.E.S.I.R. cohort. METHODS: In 3770 D.E.S.I.R. participants (sex ratio=1) averaging 47.5 years (range 30-64), with measured weight and MS parameters at baseline (D0) and at 6 year follow-up (D6), we assessed this relationship across five weight-change classes, using stable weight as the referent group (-2 to +2 kg). We used analysis-of-covariance to assess changes in each MS parameter and logistic regression to assess incident MS, according to the National Cholesterol Education Program (NCEP). We also assessed weight-change effect on MS status between D0 and D6. RESULTS: At D0, average weight was 68.4 kg (SD 12.3); BMI was 24.8 kg/m2 (SD 3.5). From D0-D6, the cohort gained a mean 2.1 kg (median 2.0; SD 4.4). After adjustment for age and D0 weight, there was a strong linear relationship with weight change and worsening of the following MS parameters at D6: fasting insulin, waist girth, fasting glucose, fasting triglycerides, HDL cholesterol, and systolic and diastolic blood pressure (P<0.0001). After age adjustment, for every kilogram gained over 6 years, risk of developing the NCEP Syndrome increased 22% (OR 1.22; 95% CI 1.18-1.25). NCEP-MS was incident in 3% of those with stable weight compared with 21% among those gaining >9 kg; 10% of those who lost >2 kg reverted to non-NCEP-MS. CONCLUSIONS: All continuous MS measures are linearly related to weight change, and MS can resolve with modest weight loss, underscoring the importance of maintaining lifelong normal weight. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0300-5771 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1093/ije/dyi281 |
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| journal : |
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| International Journal of Epidemiology (Int J Epidemiol) |
| Publisher |
Oxford University Press (OUP): Policy B |
| ISSN |
0300-5771 (eISSN : 1464-3685) |
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| Audience : |
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internationale |
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| date de publication : |
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02/2006 |
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| volume : |
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35 |
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| numéro : |
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1 |
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| page, identifiant, ... : |
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190-6 |
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| Descripteur(s) MeSH : |
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Adult – Blood Glucose – Blood Pressure – Body Composition – Cholesterol – HDL – Epidemiologic Methods – Female – France – Health Surveys – Humans – Insulin – Male – Metabolic Syndrome X – Middle Aged – Overweight – Triglycerides – Weight Gain |
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