PMID: identifier of
Pubmed reference: |
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 (11997477)  |
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| title: |
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Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes. |
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| author(s): |
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Ahmed Beggah1, Brigitte Escoubet2, Stefania Puttini1, Stephane Cailmail3, Vanessa Delage1, Antoine Ouvrard-Pascaud1, Brigitte Bocchi1, Michel Peuchmaur4, Claude Delcayre3, Nicolette Farman1, Frederic Jaisser ( ) 1 |
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| laboratory: |
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| abstract: |
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Cardiac failure is a common feature in the evolution of cardiac disease. Among the determinants of cardiac failure, the renin-angiotensin-aldosterone system has a central role, and antagonism of the mineralocorticoid receptor (MR) has been proposed as a therapeutic strategy. In this study, we questioned the role of the MR, not of aldosterone, on heart function, using an inducible and cardiac-specific transgenic mouse model. We have generated a conditional knock-down model by expressing solely in the heart an antisense mRNA directed against the murine MR, a transcription factor with unknown targets in cardiomyocytes. Within 2-3 mo, mice developed severe heart failure and cardiac fibrosis in the absence of hypertension or chronic hyperaldosteronism. Moreover, cardiac failure and fibrosis were fully reversible when MR antisense mRNA expression was subsequently suppressed. |
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| subject: |
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Life Sciences/Human health and pathology/Cardiac & Cardiovascular System
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| fulltext language: |
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English |
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| ISSN: |
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0027-8424 |
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| publication format: |
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Peer-reviewed article |
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| DOI: |
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10.1073/pnas.102673599 |
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| journal: |
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Proc Natl Acad Sci U S A |
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| publication date: |
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2002-05-14 |
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| volume: |
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99 |
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| page, identifiant, ...: |
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7160-5 |
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| MeSH Descriptor(s): |
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Aldosterone Antagonists – Animals – Base Sequence – DNA – Complementary – Disease Models – Animal – Fibrosis – Gene Expression – Heart – Heart Failure – Congestive – Mice – Transgenic – Molecular Sequence Data – Myocardium – RNA – Antisense – Messenger – Receptor |
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