Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?

Abstract : With the availability of dense maps of anonymous and frequent SNPs spanning the whole human genome, genome-wide association studies are now becoming a reality. In this paper, we discuss the utility of these approaches to detect genetic risk variants involved in complex disease susceptibility and, in the best case scenario where a signal is detected, how helpful it will be to the understanding of the pathological process.European Journal of Human Genetics advance online publication, 13 December 2006; doi:10.1038/sj.ejhg.5201753.
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Eur J Hum Genet, 2007, 15 (3), pp.260-263. 〈10.1038/sj.ejhg.5201753〉
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Catherine Bourgain, Emmanuelle Génin, Nancy Cox, Françoise Clerget-Darpoux. Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?. Eur J Hum Genet, 2007, 15 (3), pp.260-263. 〈10.1038/sj.ejhg.5201753〉. 〈inserm-00119120〉

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