PMID: identifiant
de la référence Pubmed : |
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 (16126745) |
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| titre : |
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Employment loss following HIV infection in the era of highly active antiretroviral therapies. |
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| auteur(s) : |
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Rosemary Dray-Spira1, Anne Persoz2, Faroudy Boufassa2, Alice Guéguen1, France Lert1, Thierry Allegre3, Cécile Goujard4, Laurence Meyer2, Primo Cohort Study Group |
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| laboratoire : |
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| résumé : |
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BACKGROUND: Employment is a major factor in maintaining living conditions of patients with chronic diseases. This study aimed to quantify the frequency and to identify the determinants of employment loss during the first years of HIV disease in the era of highly active antiretroviral therapies (HAART). METHODS: The French PRIMO multicentre prospective cohort of 319 patients enrolled during primary HIV-1 infection between 1996 and 2002. Employment loss was defined as moving from employment to inactivity between two visits. Characteristics associated with employment loss were assessed using generalized estimating equations. RESULTS: During a median follow-up time of 2.5 years, 56 employment losses occurred among 51 patients (18.0%). In multivariate analysis, female gender (adjusted odds ratio 3.1; 95% confidence interval 1.1-8.5), non-permanent job (3.8; 1.5-9.3) and poor accommodation (4.2; 1.6-11.2) constituted independent risk factors for employment loss; subjects with a high occupational position had a decreased risk of job loss. Moreover, an updated HIV viral load above 10 000 copies/ml either persistent (2.4; 1.1-5.0) or incident (3.7; 1.0-13.9) and hospitalization in the preceding 6 months (3.9; 1.6-9.7) constituted independent risk factors for employment loss, as tended to be a baseline CD4 cell count <350/mm(3) (1.9; 0.9-4.3) and chronic comorbidity (1.8; 0.9-3.6). CONCLUSIONS: In the HAART era, employment loss is frequent from the first months of HIV infection. Employment loss occurs especially in women and in patients with adverse socioeconomic conditions, severe HIV infection and/or comorbidity. Social interventions should seek to prevent HIV-infected patients from leaving their job from the earliest times of the disease. |
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| domaine : |
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Sciences du Vivant/Santé publique et épidémiologie
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1101-1262 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1093/eurpub/cki153 |
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| journal : |
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Eur J Public Health |
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| date de publication : |
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2006 |
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| volume : |
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16 |
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| page, identifiant, ... : |
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89-95 |
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| Descripteur(s) MeSH : |
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Adolescent – Adult – Aged – Antiretroviral Therapy – Highly Active – Employment – Female – France – HIV Infections – Humans – Male – Middle Aged – Prospective Studies – Research Support – Non-U.S. Gov't – Socioeconomic Factors |
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