Effects of high-intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogen ions in women

Abstract : The purpose of this study was to investigate the effects of high-intensity interval training (3 days/wk for 5 wk), provoking large changes in muscle lactate and pH, on changes in intracellular buffer capacity (j3min vitro), monocar- boxylate transporters (MCTs), and the decrease in muscle lactate and hydrogen ions (H+) after exercise in women. Before and after train- ing, biopsies of the vastus lateralis were obtained at rest and imme- diately after and 60 s after 45 s of exercise at 190% of maximal O2 uptake. Muscle samples were analyzed for ATP, phosphocreatine (PCr), lactate, and H+; MCT1 and MCT4 relative abundance and j3min vitro were also determined in resting muscle only. Training provoked a large decrease in postexercise muscle pH (pH 6.81). After training, there was a significant decrease in j3min vitro (-11%) and no significant change in relative abundance of MCT1 (96 + 12%) or MCT4 (120 + 21%). During the 60-s recovery after exercise, training was associated with no change in the decrease in muscle lactate, a significantly smaller decrease in muscle H+, and increased PCr resynthesis. These results suggest that increases in j3min vitro and MCT relative abundance are not linked to the degree of muscle lactate and H+ accumulation during training. Furthermore, training that is very intense may actually lead to decreases in j3min vitro. The smaller postexercise decrease in muscle H+ after training is a further novel finding and suggests that training that results in a decrease in H+ accumulation and an increase in PCr resynthesis can actually reduce the decrease in muscle H+ during the recovery from supramaximal exercise.
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The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2008, 295 (6), pp.1991-1998
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Claire Thomas, David J. Bishop, Johann Edge, Jacques Mercier. Effects of high-intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogen ions in women. The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2008, 295 (6), pp.1991-1998. 〈hal-01586192〉

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