Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats

Abstract : We tested the hypothesis that re- ducing hydrogen ion accumulation during training would result in greater improvements in muscle oxidative capacity and time to ex- haustion (TTE). Male Wistar rats were randomly assigned to one of three groups (CON, PLA, and BIC). CON served as a sedentary control, whereas PLA ingested water and BIC ingested sodium bicar- bonate 30 min prior to every training session. Training consisted of seven to twelve 2-min intervals performed five times/wk for 5 wk. Following training, TTE was significantly greater in BIC (81.2 ± 24.7 min) compared with PLA (53.5 ± 30.4 min), and TTE for both groups was greater than CON (6.5 ± 2.5 min). Fiber respiration was deter- mined in the soleus (SOL) and extensor digitorum longus (EDL), with either pyruvate (Pyr) or palmitoyl carnitine (PC) as substrates. Com- pared with CON (14.3 ± 2.6 nmol O2 • min-1 • mg dry wt-1), there was a signifi greater SOL-Pyr state 3 respiration in both PLA (19.6 ± 3.0 nmol O2 • min-1 • mg dry wt-1) and BIC (24.4 ± 2.8 nmol O2 • min-1 • mg dry wt-1), with a significantly greater value in BIC. However, state 3 respiration was significantly lower in the EDL from both trained groups compared with CON. These differences remained significant in the SOL, but not the EDL, when respiration was corrected for citrate synthase activity (an indicator of mitochondrial mass). These novel findings suggest that reducing muscle hydrogen ion accumulation during running training is associated with greater improvements in both mitochondrial mass and mitochondrial respiration in the soleus.
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American Journal of Physiology -Endocrinology and Metabolism, 2010, 299 (2), pp.225-233
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David J. Bishop, Claire Thomas, Thomas Moore-Morris, Michail Tonkonogi, Kent Sahlin, et al.. Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats. American Journal of Physiology -Endocrinology and Metabolism, 2010, 299 (2), pp.225-233. 〈hal-01585953〉

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