J. S. Sebolt-leopold and R. Herrera, Targeting the mitogen-activated protein kinase cascade to treat cancer, Nature Reviews Cancer, vol.45, issue.12, pp.937-947, 2004.
DOI : 10.1038/sj.leu.2403032

J. Downward, Targeting RAS signalling pathways in cancer therapy, Nature Reviews Cancer, vol.3, issue.1, pp.11-22, 2003.
DOI : 10.1038/nrc969

J. Massague, Integration of Smad and MAPK pathways: a link and a linker revisited, Genes & Development, vol.17, issue.24, pp.2993-2997, 2003.
DOI : 10.1101/gad.1167003

M. Aouadi, B. Binetruy, L. Caron, L. Marchand-brustel, Y. Bost et al., Role of??MAPKs in??development and??differentiation: lessons from knockout mice, Biochimie, vol.88, issue.9, pp.1091-1098, 2006.
DOI : 10.1016/j.biochi.2006.06.003

L. S. Campos, ??1 integrins activate a MAPK signalling pathway in neural stem cellsthat contributes to their maintenance, Development, vol.131, issue.14, pp.3433-3444, 2004.
DOI : 10.1242/dev.01199

C. Ge, G. Xiao, D. Jiang, and R. T. Franceschi, Critical role of the extracellular signal???regulated kinase???MAPK pathway in osteoblast differentiation and skeletal development, The Journal of Cell Biology, vol.275, issue.5, pp.709-718, 2007.
DOI : 10.1074/jbc.M109881200

O. D. Klein, Sprouty Genes Control Diastema Tooth Development via Bidirectional Antagonism of Epithelial-Mesenchymal FGF Signaling, Developmental Cell, vol.11, issue.2, pp.181-190, 2006.
DOI : 10.1016/j.devcel.2006.05.014

V. Laugel-haushalter, RSK2 Is a Modulator of Craniofacial Development, PLoS ONE, vol.30, issue.1, p.84343, 2014.
DOI : 10.1371/journal.pone.0084343.s004

I. Thesleff and M. Mikkola, The role of growth factors in tooth development, Int. Rev. Cytol, vol.217, pp.93-135, 2002.
DOI : 10.1016/S0074-7696(02)17013-6

K. Tompkins, Molecular Mechanisms of Cytodifferentiation in Mammalian Tooth Development, Connective Tissue Research, vol.117, issue.2, pp.111-118, 2006.
DOI : 10.1359/JBMR.041107

X. Xu, Ectodermal Smad4 and p38 MAPK Are Functionally Redundant in Mediating TGF-??/BMP Signaling during Tooth and Palate Development, Developmental Cell, vol.15, issue.2, pp.322-329, 2008.
DOI : 10.1016/j.devcel.2008.06.004

URL : http://doi.org/10.1016/j.devcel.2008.06.004

A. Tucker and P. Sharpe, The cutting-edge of mammalian development; how the embryo makes teeth, Nature Reviews Genetics, vol.104, issue.7, pp.499-508, 2004.
DOI : 10.1046/j.0909-8836.1998.eos106510.x

A. Neubüser, H. Peters, R. Balling, and G. Martin, Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation, Cell, vol.90, issue.2, pp.247-255, 1997.
DOI : 10.1016/S0092-8674(00)80333-5

I. Thesleff, Epithelial-mesenchymal signalling regulating tooth morphogenesis, Journal of Cell Science, vol.116, issue.9, p.1647, 2003.
DOI : 10.1242/jcs.00410

A. F. Goodwin, Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis, Clinical Genetics, vol.5, issue.6, pp.539-544, 2013.
DOI : 10.1242/dmm.008672

X. Nie, K. Luukko, and P. Kettunen, FGF signalling in craniofacial development and developmental disorders, Oral Diseases, vol.129, issue.2, pp.102-111, 2006.
DOI : 10.1002/dvdy.10457

A. O. Wilkie and G. M. Morriss-kay, GENETICS OF CRANIOFACIAL DEVELOPMENT AND MALFORMATION, Nature Reviews Genetics, vol.2, issue.6, pp.458-468, 2001.
DOI : 10.1038/35076601

N. Hacohen, S. Kramer, D. Sutherland, Y. Hiromi, and M. Krasnow, sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways, Cell, vol.92, issue.2, pp.253-263, 1998.
DOI : 10.1016/S0092-8674(00)80919-8

A. Reich, A. Sapir, and B. Shilo, Sprouty is a general inhibitor of receptor tyrosine kinase signaling, Development, vol.126, p.4139, 1999.

H. Hanafusa, S. Torii, T. Yasunaga, and E. Nishida, Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway, Nature Cell Biology, vol.19, issue.11, pp.850-858, 2002.
DOI : 10.1093/embo-reports/kvd008

S. Zhang, Y. Lin, P. Itaranta, A. Yagi, and S. Vainio, Expression of Sprouty genes 1 , 2 and 4 during mouse organogenesis, Mechanisms of Development, vol.109, issue.2, pp.367-370, 2001.
DOI : 10.1016/S0925-4773(01)00526-3

S. Lagronova-churava, The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol.49, issue.5, pp.307-327, 2013.
DOI : 10.1002/dvg.20715

A. Ohazama, Primary cilia regulate Shh activity in the control of molar tooth number, Development, vol.136, issue.6, pp.897-903, 2009.
DOI : 10.1242/dev.027979

R. Peterková, Correlation between apoptosis distribution and BMP-2 and BMP-4 expression in vestigial tooth primordia in mice, European Journal of Oral Sciences, vol.106, issue.2p1, pp.667-670, 1998.
DOI : 10.1046/j.0909-8836..t01-5-.x

L. Viriot, The presence of rudimentary odontogenic structures in the mouse embryonic mandible requires reinterpretation of developmental control of first lower molar histomorphogenesis, Int. J. Dev. Biol, vol.44, pp.233-240, 2000.

L. Viriot, R. Peterková, M. Peterka, and H. Lesot, Evolutionary Implications of the Occurrence of Two Vestigial Tooth Germs During Early Odontogenesis in the Mouse Lower Jaw, Connective Tissue Research, vol.30, issue.2-3, pp.129-133, 2002.
DOI : 10.1007/BF03022555

M. Frödin and S. Gammeltoft, Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction, Molecular and Cellular Endocrinology, vol.151, issue.1-2, pp.65-77, 1999.
DOI : 10.1016/S0303-7207(99)00061-1

Y. Romeo, RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth, Oncogene, vol.63, issue.24, pp.2917-2926, 2012.
DOI : 10.1016/j.cub.2008.07.078

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440665

A. Hanauer and I. D. Young, Coffin-Lowry syndrome: clinical and molecular features, Journal of Medical Genetics, vol.39, issue.10, pp.705-713, 2002.
DOI : 10.1136/jmg.39.10.705

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1734994

S. A. Temtamy, The Coffin-Lowry syndrome: a simply inherited trait comprising mental retardation, faciodigital anomalies and skeletal involvement, Birth Defects Orig. Artic. Ser, vol.11, pp.133-152, 1974.
DOI : 10.1016/s0022-3476(75)80357-x

S. A. Temtamy, J. D. Miller, and I. Hussels-maumenee, The Coffin-Lowry syndrome: An inherited faciodigital mental retardation syndrome, The Journal of Pediatrics, vol.86, issue.5, pp.724-731, 1975.
DOI : 10.1016/S0022-3476(75)80357-X

C. Charles, Distinct Impacts of Eda and Edar Loss of Function on the Mouse Dentition, PLoS ONE, vol.306, issue.2, p.4985, 2009.
DOI : 10.1371/journal.pone.0004985.g003

URL : https://hal.archives-ouvertes.fr/hal-00374374

H. J. Kim and D. Bar-sagi, Modulation of signalling by Sprouty: a developing story, Nature Reviews Molecular Cell Biology, vol.59, issue.6, pp.441-450, 2004.
DOI : 10.1101/SQB.1994.059.01.021

T. Åberg, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis, Developmental Biology, vol.270, issue.1, pp.76-93, 2004.
DOI : 10.1016/j.ydbio.2004.02.012

L. B. Corson, Y. Yamanaka, K. V. Lai, and J. Rossant, Spatial and temporal patterns of ERK signaling during mouse embryogenesis, Development, vol.130, issue.19, pp.4527-4537, 2003.
DOI : 10.1242/dev.00669

C. Charles, Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition, Proc. Natl. Acad. Sci, p.22364, 2009.
DOI : 10.1242/dev.00881

URL : https://hal.archives-ouvertes.fr/hal-00488217

X. P. Wang, An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth, PLoS Biology, vol.25, issue.6, p.159, 2007.
DOI : 10.1371/journal.pbio.0050159.sg003

URL : http://doi.org/10.1371/journal.pbio.0050159

L. Chang and M. Karin, Mammalian MAP kinase signalling cascades, Nature, vol.410, issue.6824, pp.37-40, 2001.
DOI : 10.1038/35065000

Y. Ahn, B. W. Sanderson, O. D. Klein, and R. Krumlauf, Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning, Development, vol.137, issue.19, p.3221, 2010.
DOI : 10.1242/dev.054668

A. Ohazama, Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development, PLoS ONE, vol.124, issue.12, p.4092, 2008.
DOI : 10.1371/journal.pone.0004092.s004

X. P. Wang, Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood, Development, vol.136, issue.11, p.1939, 2009.
DOI : 10.1242/dev.033803

A. T. Kangas, A. R. Evans, I. Thesleff, and J. Jernvall, Nonindependence of mammalian dental characters, Nature, vol.79, issue.7014, pp.211-214, 2004.
DOI : 10.1002/dvdy.20138

J. Luo, N. L. Solimini, and S. J. Elledge, Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction, Cell, vol.136, issue.5, pp.823-837, 2009.
DOI : 10.1016/j.cell.2009.02.024

URL : http://doi.org/10.1016/j.cell.2009.02.024

B. Moon, Role of Oncogenic K-Ras in Cancer Stem Cell Activation by Aberrant Wnt/??-Catenin Signaling, JNCI: Journal of the National Cancer Institute, vol.106, issue.2, p.373, 2014.
DOI : 10.1093/jnci/djt373

P. Hershkovitz, Evolution of neotropical cricetine rodents (Muridae): with special reference to the phyllotine Group, Fieldiana, Zool, vol.48, pp.1-524, 1962.
DOI : 10.5962/bhl.title.2781

R. Peterková, H. Lesot, J. L. Vonesch, M. Peterka, and J. Ruch, Mouse molar morphogenesis revisited by three dimensional reconstruction. I. Analysis of initial stages of the first upper molar development revealed two transient buds, Int. J. Dev. Biol, vol.40, pp.1009-1016, 1996.

L. Hamel, Ancient signals: comparative genomics of plant MAPK and MAPKK gene families, Trends in Plant Science, vol.11, issue.4, pp.192-198, 2006.
DOI : 10.1016/j.tplants.2006.02.007

Y. Li, Z. Yun-xiang, and X. Xiang-xu, The composition of three mammal faunas and environmental evolution in the last glacial maximum, Guanzhong area, Shaanxi Province, China, Quaternary International, vol.248, pp.86-91, 2012.
DOI : 10.1016/j.quaint.2011.02.009

Z. Pucek, J. Niethammer, and F. Krapp, Sicista betulina (Pallas, 1778)-Waldbirkenmaus, Handb. Säugetiere Eur. Bd, vol.2, pp.516-538, 1982.

G. Rodrigues, H. Charles, C. Marivaux, L. Vianey-liaud, M. Viriot et al., Evolutionary and developmental dynamics of the dentition in Muroidea and Dipodoidea (Rodentia, Mammalia), Evolution & Development, vol.35, issue.4, pp.361-369, 2011.
DOI : 10.1016/j.archoralbio.2004.10.003

P. Fabre, L. Hautier, D. Dimitrov, and E. J. Douzery, A glimpse on the pattern of rodent diversification: a phylogenetic approach, BMC Evolutionary Biology, vol.12, issue.1, p.88, 2012.
DOI : 10.1098/rstb.2011.0025

Y. S. Tong, Pappocricetodon, a pre-Oligocene cricetid genus (Rodentia) from central China, Vertebr. Palasiat, vol.30, pp.1-16, 1992.

Y. Kimura, L. L. Jacobs, and L. J. Flynn, Lineage-Specific Responses of Tooth Shape in Murine Rodents (Murinae, Rodentia) to Late Miocene Dietary Change in the Siwaliks of Pakistan, PLoS ONE, vol.2, issue.10, p.76070, 2013.
DOI : 10.1371/journal.pone.0076070.s007

X. Yang, ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology, Cell, vol.117, issue.3, pp.387-398, 2004.
DOI : 10.1016/S0092-8674(04)00344-7

P. Tafforeau, Applications of X-ray synchrotron microtomography for non-destructive 3D studies of paleontological specimens, Applied Physics A, vol.385, issue.2, pp.195-202, 2006.
DOI : 10.1007/s00339-006-3507-2

URL : https://hal.archives-ouvertes.fr/hal-00174890