First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue BMC Infectious Diseases Année : 2015

First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs

Résumé

Background : The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs). Methods : Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009–10. Admission and weekly screenings were performed by using selective media for methicillin resistant Staphylococcus aureus, extended-spectrum beta-lactamase-producing Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa. For the two latters, resistance to ceftazidime defined MDRO. Backward logistic regression models were designed to assess factors independently associated with MDRO carriage on admission and MDRO acquisition within ICUs. Results : 686 patients were included, and the MDRO prevalence rate on admission was 30.5 % (32.7 % for ESBL-positive Enterobacteriaceae, 3.2 % for MRSA). Antibiotic treatment prior to ICU admission was independently associated with carriage on admission (OR: 1.4) in multivariate analysis. A total of 104 patients acquired ≥1 MDRO in ICU (overall attack rate: 23.7 %; 14.9 % for ESBL-positive Enterobacteriaceae, and 5.1 % for MRSA). The MDRO attack rate increased from 13.2 % in the first week to 82.1 % for ICU stay > 3 weeks. Duration of antibiotic exposure (OR: 1.16; 1.1–1.2) and prior antibiotic treatment before ICU (OR: 2.1; 1.1–3.3) were associated with MDRO acquisition in multivariate analysis. The MDRO prevalence rate on ICU discharge was 51.2 % and the global prevalence density rate 71 per 1000 hospital-days. Conclusion : More than one out of two patients was MDRO carrier on ICU discharge in Chinese hospitals. This is the result of the combination of a high MDRO prevalence rate on ICU admission and a high MDRO acquisition rate within ICU.
Fichier principal
Vignette du fichier
Ma_2015_First_multicenter.pdf (570.34 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01188052 , version 1 (28-08-2015)

Licence

Paternité

Identifiants

Citer

Xiaojun Ma, Yinghong Wu, Liuyi Li, Qian Xu, Bijie Hu, et al.. First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs. BMC Infectious Diseases, 2015, 15 (1), pp.358. ⟨10.1186/s12879-015-1105-7⟩. ⟨hal-01188052⟩
253 Consultations
144 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More