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S. Reports and . Deville, The symbols for author attributes were incorrect. S. Deville is the author to whom correspondence should be addressed (e-mail: sdeville@lbl.gov), and the present address for R. K. Nalla is Intel Corporation, 5000 West Chandler Boulevard, Chandler, AZ 85226, USA. TECHNICAL COMMENT ABSTRACTS Comment on " HST2 Mediates SIR2- Independent Life-Span Extension by Calorie Restriction Kennedy Calorie restriction (CR) increases life span in yeast independently of Sir2) recently proposed that Sir2- independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Response to Comment on " HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction, pp.515-1861312, 1312.