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Fig. 3.   Registration results on a patient with MS lesions in the spinal cord

(a) patient image at time point t0; (b) patient image at time point t1 registered with M1 and (e) with M3; (d,g) zoom on (b,e); (h) zoom on (a); (c,f) zoom on the difference (registered minus reference) image. Note that in this case M2 (not displayed) performs as well as M3. These snapshots, and in particular the zoomed difference images, visually show that M3 gives a better result than a simple global rigid registration.

Med Image Comput Comput Assist Interv. 2012; 15(Pt 2): 163–70.
doi: 10.1007/978-3-642-33418-4_21.