Factors influencing the time to undectability (HBV-DNA < 200 copies/mL), univariate analysis
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Factors influencing the time to undectability (HBV-DNA < 200 copies/mL), univariate analysis
| Crude Hazard Ratio | CI 95% | p | |
|---|---|---|---|
| TDF v. ADV | 2.22 | (0.99–4.94) | 0.05 |
| HBV load at baseline | |||
| - per log10 copies/mL HBV-DNA | 0.66 | (0.55–0.80) | <0.001 |
| - < 2000 copies/mL | 1.00 | ** | ** |
| - 2000 – 10,000 copies/mL | 0.12 | (0.03–0.46) | 0.002 |
| - > 10,000 copies/mL | 0.05 | (0.02–0.14) | <0.001 |
| Presence of HBe antigen in serum | 0.13 | (0.04–0.41) | <0.001 |
| Presence of YMDD mutation | 0.77 | (0.29–2.07) | 0.6 |
| Presence of Pre C mutation | 0.60 | (0.28–1.28) | 0.2 |
| HIV load at baseline (per log10 HIV-RNA) | 0.85 | (0.47–1.54) | 0.6 |
| Duration of HIV infection (per year) | 0.95 | (0.88–1.02) | 0.14 |
| CD4+ Cell Count (≥ 402/mm3) | 0.74 | (0.42–1.31) | 0.3 |
| METAVIR Fibrosis F0–F2 vs F3–F4 | 1.72 | (0.78–3.79) | 0.2 |
| ALT level at baseline (≥72 UI/mL = median) | 0.46 | (0.25–0.85) | 0.01 |
| Additional HCV co-infection | 1.42 | (0.44–4.58) | 0.6 |
| Alcohol consumption (cut at the median) | 0.71 | (0.40–1.29) | 0.3 |